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High density plate filler

  • US 7,407,630 B2
  • Filed: 03/22/2005
  • Issued: 08/05/2008
  • Est. Priority Date: 09/19/2003
  • Status: Active Grant
First Claim
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1. A filling apparatus for filling a microplate, said microplate having a plurality of wells, each of said plurality of wells being sized to receive an assay therein, said filling apparatus comprising:

  • a first layer having a first surface and an opposing second surface, said first layer further having an assay input port for receiving the assay extending from said first surface to said second surface, a venting manifold formed in said second surface, and a vent hole in fluid communication with said venting manifold and atmosphere, said venting manifold and said vent hole being distinct from said assay input port;

    a second layer having a plurality of staging capillaries, each of said plurality of staging capillaries having an inlet and an outlet and being sized to receive the assay, said second layer having a plurality of microfluidic channels formed therein, at least one of said plurality of microfluidic channels being in fluid communication with said inlets of at least a pair of said plurality of staging capillaries; and

    a third layer disposed between said first layer and said second layer, said third layer further having a flow aperture being in fluid communication with said assay input port and said plurality of microfluidic channels, said third layer further having a plurality of vent apertures each in fluid communication with at least one of said plurality of staging capillaries, two or more of said plurality of vent apertures being in fluid communication with said venting manifold and distinct from said plurality of staging capillaries and said plurality of microfluidic channels.

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