Engineered zinc finger proteins for regulation of gene expression
First Claim
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1. An isolated polynucleotide comprising a nucleic acid sequence encoding an engineered zinc finger protein, the engineered zinc finger protein comprising six zinc fingers, each zinc finger comprising a recognition region, wherein the amino acid sequence of the recognition regions, in amino- to carboxy-terminal order, are as follows:
- RSDHLSR (SEQ ID NO;
1);
DNRDRTK (SEQ ID NO;
2);
DRKTLIE (SEQ ID NO;
3);
TSSGLSR (SEQ ID NO;
4);
RSDHLSE (SEQ ID NO;
5);
TSSDRTK (SEQ ID NO;
6).
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Abstract
Disclosed herein are methods and compositions for modulation of gene expression, with single-gene specificity, in a human-sized genome.
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10 Claims
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1. An isolated polynucleotide comprising a nucleic acid sequence encoding an engineered zinc finger protein, the engineered zinc finger protein comprising six zinc fingers, each zinc finger comprising a recognition region, wherein the amino acid sequence of the recognition regions, in amino- to carboxy-terminal order, are as follows:
- RSDHLSR (SEQ ID NO;
1);
DNRDRTK (SEQ ID NO;
2);
DRKTLIE (SEQ ID NO;
3);
TSSGLSR (SEQ ID NO;
4);
RSDHLSE (SEQ ID NO;
5);
TSSDRTK (SEQ ID NO;
6). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
- RSDHLSR (SEQ ID NO;
Specification