Monitoring the sympathico-vagal activity by analysis of endocardiac acceleration in an active implantable medical device

• US 7,409,241 B2
• Filed: 11/22/2004
• Issued: 08/05/2008
• Est. Priority Date: 11/21/2003
• Status: Active Grant

• Current Assignee: Ela Medical S.A. (LivaNova Plc)
• Original Assignee: Sorin CRM SAS
• Inventors: Gaggini, Guido, Vitali, Luca
• Primary Examiner(s): Layno; Carl H.
• Assistant Examiner(s): MALAMUD, DEBORAH LESLIE
• Application Number:
  US10/995,591
• Publication Number:
  US 20050131470A1
• Time in Patent Office: 1,352 Days
• Field of Search: 607/9, 607/17, 607/19, 607/23, 607/44, 600/527, 600508-509, 600/513
• US Class Current: 600/513
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration

Abstract

An active implantable medical device having a function for monitoring the sympathico-vagal activity by an analysis of endocardiac acceleration. The device collects at least one physiological parameter of the patient, analyzes that collected parameter and delivers at an output data representative of the sympathico-vagal activity of the patient. The physiological parameter is an endocardiac acceleration (EA), and the representative data include at least one value function of the endocardiac acceleration, in particular a function of a first peak (PEA I) at the time of the phase of isovolumic ventricular contraction and/or of a second peak (PEA II) at the time of the phase of isovolumic ventricular relieving.

Claims

1. An active implantable medical device, including:

means for collecting an endocardiac acceleration parameter of a patient;

means for analyzing said collected endocardiac acceleration signal including means for determining a first peak endocardiac acceleration (PEA I) corresponding to a phase of isovolumic ventricular contraction in a given cardiac cycle and a second peak endocardiac acceleration (PEA II) corresponding to a phase of isovolumic ventricular relaxation in said given cardiac cycle, and means for determining a heart rate of a patient;

means for calculating a long-term average and a short-term average of the values of the first peaks of endocardiac acceleration (PEA I) collected at the time of the phase of isovolumic ventricular contraction during a plurality of successive cycles;

means for calculating a long-term average and a short-term average of the values of the second peaks of endocardiac acceleration (PEA II) collected at the time of the phase of isovolumic ventricular contraction collected during a plurality of successive cycles;

means for calculating a long-term average and a short-term average of the values of heart rate;

means for delivering at an output a data representative of sympathico-vagal activity of the patient, wherein said data representative of sympathico-vagal activity comprises said calculated long-term and short-term averages of said first peak, second peak, and heart rate; and

means for detecting a risk of syncope when the short-term average of the values of the second peaks of endocardiac acceleration (PEA II) is less than the long-term average of the values of the second peaks of endocardiac acceleration (PEA II) and the short-term average of the values of heart rate is greater than the long-term average of the values of heart rate.

2. The device of claim 1, further comprising means for delivering at an output an alarm signal in response to a detected risk of imminent occurrence of a syncope.

3. The device of claim 2, further comprising means for delivering a therapy in response to a delivered alarm signal.

4. The device of claim 3 wherein said therapy delivering means further comprises means for modifying an operating parameter of said device.

5. The device of claim 3 wherein said therapy delivering means further comprises means for releasing a therapeutic function of said device.

6. The device of claim 2, wherein the detecting means further comprises means for comparing said representative data with a predetermined threshold and producing said alarm signal at a crossing of said threshold.

7. The device of claim 2, wherein said detecting means further comprises a state machine able to compare said representative data with a plurality of predetermined thresholds, and means for detecting crossings of said thresholds, analyzing a sequence of said crossings, and producing an alarm signal in response to said sequence of crossings corresponding to a preselected crossing sequence.

8. The device of claim 2, wherein said analysing means further comprises means for applying to the detected endocardiac acceleration physiological parameter an autocorrelation process selected from among the group consisting of a morphological analysis, a frequential analysis, and a wavelets analysis.

9. The device of claim 2, wherein the means for detecting further comprises means for producing an alarm signal when, by a factor of proportionality, the short-term average of the values of the second peaks of acceleration is lower than the long-term average of the values of the second peaks of acceleration and the short-term average of the values of heart rate is higher than the long-term average of the values of heart rate, for a given percentage of cycles over a predetermined number of successive cycles.

10. The device of claim 2, wherein the means for detecting further comprises means for producing an alarm signal when, by a factor of proportionality, the short-term average of the values of the first peaks of acceleration is lower than the long-term average of the values of the first peaks of acceleration and the short-term average of the values of heart rate is higher than the long-term average of the values of heart rate, for a percentage given of cycles over a predetermined number of successive cycles.

11. An active implantable medical device comprising a computer readable medium encoded with one or more computer programs performing the steps of:

collecting an endocardiac acceleration parameter of a patient;

analyzing said collected endocardiac acceleration signal including determining a first peak endocardiac acceleration (PEA I) corresponding to a phase of isovolumic ventricular contraction in a given cardiac cycle and a second peak endocardiac acceleration (PEA II) corresponding to a phase of isovolumic ventricular relaxation in said given cardiac cycle, and determining a heart rate of a patient;

calculating a long-term average and a short-term average of the values of the first peaks of endocardiac acceleration (PEA I) collected at the time of the phase of isovolumic ventricular contraction during a plurality of successive cycles;

calculating a long-term average and a short-term average of the values of the second peaks of endocardiac acceleration (PEA II) collected at the time of the phase of isovolumic ventricular contraction collected during a plurality of successive cycles;

calculating a long-term average and a short-term average of the values of heart rate;

delivering at an output a data representative of sympathico-vagal activity of the patient, wherein said data representative of sympathico-vagal activity comprises said calculated long-term and short-term averages of said first peak, second peak, and heart rate; and

detecting a risk of syncope when the short-term average of the values of the second peaks of endocardiac acceleration (PEA II) is less than the long-term average of the values of the second peaks of endocardiac acceleration (PEA II) and the short-term average of the values of heart rate is greater than the long-term average of the values of heart rate.