GLP-2 compounds, formulations, and uses thereof
First Claim
Patent Images
1. A peptide comprising the amino acid sequence of formula I:
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His-X2-X3-Gly-X5-Phe-X7-X8-X9-X10-X11-X12-X13-X14-X15-X16-X17-X18-Ala-Arg-X21-Phe-Ile-X24-Trp-Leu-Ile-X28-Thr-Arg-Ile-Thr-X33
(formula I)wherein X2 is Ala, Val, or Gly;
X3 is Asp or Glu;
X5 is Ser or Lys;
X7 is Ser or Lys;
X8 is Asp, Glu, or Lys;
X9 is Asp, Glu, or Lys;
X10 is Met, Lys, Leu, Ile, or Nor-Leucine;
X11 is Asn or Lys;
X12 is Thr or Lys;
X13 is Ile or Lys;
X14 is Leu or Lys;
X15 is Asp or Lys;
X16 is Asn or Lys;
X17 Leu or Lys;
X18 is Ala or Lys;
X21 is Asp or Lys;
X24 is Asn or Lys;
X28 is Gln or Lys;
X33 is Asp, Glu, or Lys and at least one of X5, X7, X8, X9, X10, X11, X12, X13, X14, X15, X16, X17, and X18, X21, X24, X28, X33is a Lys.
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Abstract
The present invention relates to novel human glucagon-like peptide-2 (GLP-2) peptides and human glucagon-like peptide-2 derivatives which have a protracted profile of action as well as polynucleotide constructs encoding such peptides, vectors and host cells comprising and expressing the polynucleotide, pharmaceutical compositions, uses and methods of treatment.
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Citations
31 Claims
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1. A peptide comprising the amino acid sequence of formula I:
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His-X2-X3-Gly-X5-Phe-X7-X8-X9-X10-X11-X12-X13-X14-X15-X16-X17-X18-Ala-Arg-X21-Phe-Ile-X24-Trp-Leu-Ile-X28-Thr-Arg-Ile-Thr-X33
(formula I)wherein X2 is Ala, Val, or Gly;
X3 is Asp or Glu;
X5 is Ser or Lys;
X7 is Ser or Lys;
X8 is Asp, Glu, or Lys;
X9 is Asp, Glu, or Lys;
X10 is Met, Lys, Leu, Ile, or Nor-Leucine;
X11 is Asn or Lys;
X12 is Thr or Lys;
X13 is Ile or Lys;
X14 is Leu or Lys;
X15 is Asp or Lys;
X16 is Asn or Lys;
X17 Leu or Lys;
X18 is Ala or Lys;
X21 is Asp or Lys;
X24 is Asn or Lys;
X28 is Gln or Lys;
X33 is Asp, Glu, or Lys and at least one of X5, X7, X8, X9, X10, X11, X12, X13, X14, X15, X16, X17, and X18, X21, X24, X28, X33is a Lys. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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Specification