Cytological imaging system and method
First Claim
Patent Images
1. An optical instrument lighting system for illuminating stained biological material fixed on a slide, comprising:
- a light source comprising an LED microchip module, the module comprising a substrate and an array of closely spaced LEDs, including a first LED having a first narrow band wavelength and a second LED having a second narrow band wavelength different from the first narrow band wavelength, the first and second LEDs located side-by-side and being separately controllable; and
at least one lens disposed between the light source and the slide,wherein the light source illuminates the slide using light emitted from one or both of the first and second LEDs, without dichroic mixing of the light, and without the light passing through a bandwidth filter,the array of LEDs including one or more red LEDs and one or more green LEDs, the one or more red LEDs and the one or more green LEDs attached to the substrate, and a plurality of lenses, including a first lens positioned over at least one red LED, and a second lens positioned over at least one green LEDwherein the one or more red LEDs and the one or more green LEDs are embedded in a potting material, and wherein the first and second lenses are attached to the potting material.
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Abstract
The present invention relates to the analysis of cytological material. Specifically, the invention relates to stains and methods of producing the stains, methods of staining cells for cytological or histological analysis to contrast the nuclear portion of the cell from the cytoplasmic portion, and systems and methods for illuminating a cytological sample. The analysis can be automated or manual.
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Citations
10 Claims
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1. An optical instrument lighting system for illuminating stained biological material fixed on a slide, comprising:
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a light source comprising an LED microchip module, the module comprising a substrate and an array of closely spaced LEDs, including a first LED having a first narrow band wavelength and a second LED having a second narrow band wavelength different from the first narrow band wavelength, the first and second LEDs located side-by-side and being separately controllable; and at least one lens disposed between the light source and the slide, wherein the light source illuminates the slide using light emitted from one or both of the first and second LEDs, without dichroic mixing of the light, and without the light passing through a bandwidth filter, the array of LEDs including one or more red LEDs and one or more green LEDs, the one or more red LEDs and the one or more green LEDs attached to the substrate, and a plurality of lenses, including a first lens positioned over at least one red LED, and a second lens positioned over at least one green LED wherein the one or more red LEDs and the one or more green LEDs are embedded in a potting material, and wherein the first and second lenses are attached to the potting material. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. An optical instrument lighting system for illuminating a biological sample, the system comprising an LED array, the LED array comprising:
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a substrate; a first narrow band wavelength LED consisting of a first die attached to the substrate; a second narrow band wavelength LED consisting of a second die attached to the substrate, the first narrowband wavelength different from the second narrowband wavelength, the first and second dies attached side-by-side to the substrate such the first and second LEDs fall within a 4 mm diameter; and a plurality of lenses, including a first lens positioned over the first die, and a second lens positioned over the second die, wherein the lighting system illuminates the sample using light emitted from one or both of the first and second LEDs, without the light passing through a bandwidth filter, wherein the first and second dies are embedded in a potting material, and wherein the first and second lenses are attached to the potting material.
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Specification