Apparatus for electroporation mediated delivery for drugs and genes
First Claim
Patent Images
1. A method for the introduction of an agent into cells of a tissue, said method comprising:
- a) introducing the agent into tissue; and
b) applying at least one voltage pulse between a plurality of opposing pairs of needle electrodes disposed in the tissue so as to establish an electric field in cells of the tissue sufficient to cause electroportion of cells in the tissue, thereby introducing said agent into the cells of the tissue.
3 Assignments
0 Petitions
Accused Products
Abstract
A device for in vivo electroporation therapy comprising an electrode applicator with at least two pairs of electrodes arranged relative to one another to form an array and a power supply. The device is used to generate an electric field in a biological sample and effect introduction of selected molecules into cells of the sample.
-
Citations
31 Claims
-
1. A method for the introduction of an agent into cells of a tissue, said method comprising:
-
a) introducing the agent into tissue; and
b) applying at least one voltage pulse between a plurality of opposing pairs of needle electrodes disposed in the tissue so as to establish an electric field in cells of the tissue sufficient to cause electroportion of cells in the tissue, thereby introducing said agent into the cells of the tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
-
-
26. A method for the introduction of an agent into cells of a tissue, said method comprising:
-
a) introducing the agent locally into tissue by a route other than dermal absorption; and
b) applying voltage pulses to opposing pairs of electrodes disposed in the tissue so as to establish an electric field in the tissue sufficient to cause the agent to enter cells of the tissue, thereby introducing said agent into cells of the tissue. - View Dependent Claims (27, 28, 29, 30)
-
-
31. A method of electroporating an agent into cells of a tissue, comprising:
-
a) introducing a therapeutic agent into a tissue of a patient in need of treatment; and
b) using an electrode apparatus placed in contact with the tissue to deliver voltage pulses that establish electric fields sufficient to introduce the therapeutic agent into cells of the tissue by way of electroporation, wherein the electrode apparatus comprises;
i. a support member having disposed thereon two or more opposing pairs of needle electrodes arranged relative to one another to form an electrode array; and
ii. a power supply in electrical communication with pairs of needle electrodes disposed in the support member, wherein the power supply provides voltage pulses to at least two of the opposing pairs of needle electrodes to effect electroporation.
-
Specification