Automatic sensing vector selection for morphology-based capture verification

• US 7,412,287 B2
• Filed: 12/22/2003
• Issued: 08/12/2008
• Est. Priority Date: 12/22/2003
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Yonce, David J., Ternes, David
• Primary Examiner(s): Sykes; Angela D.
• Assistant Examiner(s): ALTER, ALYSSA MARGO
• Application Number:
  US10/744,911
• Publication Number:
  US 20050137638A1
• Time in Patent Office: 1,695 Days
• Field of Search: 607/27, 607/28, 607/9, 600/510
• US Class Current: 607/28
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36842 Multi-site stimulation in the same chamber
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation
• CPC Class Codes: A61N 1/3712 Auto-capture, i.e. automatic adjustment of the stimulation threshold

Abstract

A system and method for verifying capture of the heart by one or more pacing pulses using an electrogram morphology-based technique. Capture is determined by comparing an evoked response electrogram recorded during a paced cycle with a template waveform representing a paced cycle in which capture is achieved. The comparison is facilitated and made more accurate by selecting a sensing vector in which an evoked response electrogram in which no capture occurs is most dissimilar to the template.

Claims

1. A method for verifying capture by a cardiac pacemaker, comprising:

delivering biventricular pacing during a paced cardiac cycle;

recording an evoked response electrogram during a paced cardiac cycle;

comparing the waveform of the evoked response electrogram with template waveforms representing biventricular, left ventricle-only, and right ventricle-only capture;

determining that either biventricular, left ventricle-only, or right ventricle-only capture has occurred during the paced cardiac cycle if the degree of similarity between the evoked response and one of the biventricular, left ventricle-only, or right ventricle-only capture template waveforms is above a specified threshold; and

,

selecting an optimum sensing vector for generating the evoked response and template waveforms by generating biventricular, left ventricle-only, and right ventricle-only capture templates using a plurality of different sensing vectors and selecting the optimum sensing vector as that sensing vector for which the biventricular capture template is least similar to one or both of the left ventricle-only and right ventricle-only capture templates.

2. The method of claim 1 further comprising:

comparing the waveform of the evoked response electrogram with template waveforms representing biventricular, left ventricle-only, and right ventricle-only capture by cross-correlating the waveform of the evoked response electrogram with the template waveforms representing biventricular, left ventricle-only, and right-ventricle-only capture;

determining that capture has occurred during the paced cardiac cycle if the correlation between the evoked response and one of the template waveforms is a above a specified threshold.

3. The method of claim 1 further comprising:

selecting an optimum sensing vector for detecting right ventricle-only capture as that sensing vector for which the biventricular capture template is least similar to the fight ventricle-only template; and

,

selecting an optimum sensing vector for detecting left ventricle-only capture as that sensing vector for which the biventricular capture template is least similar to the left ventricle-only template.

4. The method of claim 1 further comprising selecting the optimum sensing vector as that sensing vector for which the biventricular capture template is least similar to whichever of the left ventricle-only and right ventricle-only capture templates is most similar to the biventricular capture template.

5. The method of claim 1 further comprising selecting the optimum sensing vector as that sensing vector for which the biventricular capture template is least correlated to whichever of the left ventricle-only and right ventricle-only capture templates is most correlated to the biventricular capture template.

6. The method of claim 1 wherein the plurality of sensing vectors are formed by selecting particular switchable electrodes of the pacemaker for recording electrograms.

7. The method of claim 1 wherein the plurality of sensing vectors are formed by selecting particular leads of a surface ECG apparatus for recording electrograms.

8. The method of claim 1 wherein the sensing vector is selected prior to performing a threshold test for determining an appropriate pacing pulse energy for the pacemaker.

9. The method of claim 1 wherein the sensing vector is selected during a template acquisition routine in which a template representing biventricular capture is generated.

10. A system for verifying capture by an implantable cardiac pacemaker, comprising:

an implantable cardiac pacemaker configured to deliver biventricular pacing;

an external programmer in communication with the pacemaker via a wireless telemetry link; and

,

wherein the external programmer is configured to;

store an evoked response electrogram recorded during a paced cardiac cycle;

compare the waveform of the evoked response electrogram with template waveforms representing biventricular, left ventricle-only, and right ventricle-only capture;

determine that either biventricular, left ventricle-only, or right ventricle-only capture has occurred during the paced cardiac cycle if the degree of similarity between the evoked response and one of the biventricular, left ventricle-only, or right ventricle-only capture template waveforms is above a specified threshold; and

,

select an optimum sensing vector for generating the evoked response and template waveforms by generating biventricular, left ventricle-only, and right ventricle-only capture templates using a plurality of different sensing vectors and selecting the optimum sensing vector as that sensing vector for which the biventricular capture template is least similar to one or both of the left ventricle-only and right ventricle-only capture templates.

11. The system of claim 10 wherein the external programmer is configured to:

compare the waveform of the evoked response electrogram with template waveforms representing biventricular, left ventricle-only, and right ventricle-only capture by cross-correlating the waveform of the evoked response electrogram with the template waveforms representing biventricular, left ventricle-only, and right-ventricle-only capture;

determine that capture has occurred during the paced cardiac cycle if the correlation between the evoked response and one of the template waveforms is a above a specified threshold.

12. The system of claim 10 wherein the external programmer is configured to:

select an optimum sensing vector for detecting right ventricle-only capture as that sensing vector for which the biventricular capture template is least similar to the right ventricle-only template; and

,

select an optimum sensing vector for detecting left ventricle-only capture as that sensing vector for which the biventricular capture template is least similar to the left ventricle-only template.

13. The system of claim 10 wherein the external programmer is configured to select the optimum sensing vector as that sensing vector for which the biventricular capture template is least similar to whichever of the left ventricle-only and right ventricle-only capture templates is most similar to the biventricular capture template.

14. The system of claim 10 wherein the external programmer is further configured to select the optimum sensing vector as that sensing vector for which the biventricular capture template is least correlated to whichever of the left ventricle-only and right ventricle-only capture templates is most correlated to the biventricular capture template.

15. The system of claim 10 wherein the evoked response electrogram is an electrogram transmitted to the external programmer by the pacemaker and further wherein the plurality of sensing vectors are formed by selecting particular switchable electrodes for incorporating into a sensing channel of the pacemaker for recording electrograms.

16. The system of claim 10 wherein the plurality of sensing vectors are formed by selecting particular leads of a surface ECG apparatus incorporated into the external programmer for recording electrograms.

17. The system of claim 10 wherein the external programmer is configured to automatically select the sensing vector prior to performing a threshold test for determining an appropriate pacing pulse energy for the pacemaker.

18. The system of claim 10 wherein the external programmer is configured to automatically select the sensing vector during a template acquisition routine in which a template representing biventricular capture is generated.

19. An implantable cardiac pacemaker, comprising:

a pacing channel for delivering pacing pulses;

a sensing channel for generating electrogram signals;

a controller for controlling the operation of the pacemaker, wherein the controller is configured to;

store an evoked response electrogram recorded during a paced cardiac cycle;

compare the waveform of the evoked response electrogram with template waveforms representing biventricular, left ventricle-only, and right ventricle-only capture;

determine that either biventricular, left ventricle-only, or right ventricle-only capture has occurred during the paced cardiac cycle if the degree of similarity between the evoked response and one of the biventricular, left ventricle-only, or right ventricle-only capture template waveforms is above a specified threshold; and

,

select an optimum sensing vector for generating the evoked response and template waveforms by generating biventricular, left ventricle-only, and right ventricle-only capture templates using a plurality of different sensing vectors and selecting the optimum sensing vector as that sensing vector for which the biventricular capture template is least similar to one or both of the left ventricle-only and right ventricle-only capture templates.

20. The pacemaker of claim 19 wherein the controller is configured to:

compare the waveform of the evoked response electrogram with template waveforms representing biventricular, left ventricle-only, and right ventricle-only capture by cross-correlating the waveform of the evoked response electrogram with the template waveforms representing biventricular, left ventricle-only, and right-ventricle-only capture;

determine that capture has occurred during the paced cardiac cycle if the correlation between the evoked response and one of the template waveforms is a above a specified threshold.

21. The pacemaker of claim 19 wherein the controller is configured to:

select an optimum sensing vector for detecting right ventricle-only capture as that sensing vector for which the biventricular capture template is least similar to the right ventricle-only template; and

,

select an optimum sensing vector for detecting left ventricle-only capture as that sensing vector for which the biventricular capture template is least similar to the left ventricle-only template.

22. The pacemaker of claim 19 wherein the controller is configured to select the optimum sensing vector as that sensing vector for which the biventricular capture template is least similar to whichever of the left ventricle-only and right ventricle-only capture templates is most similar to the biventricular capture template.

23. The pacemaker of claim 19 wherein the controller is further configured to select the optimum sensing vector as that sensing vector for which the biventricular capture template is least correlated to whichever of the left ventricle-only and right ventricle-only capture templates is most correlated to the biventricular capture template.

24. The pacemaker of claim 19 wherein the plurality of sensing vectors are formed by selecting particular switchable electrodes for incorporating into a sensing channel of the pacemaker for recording electrograms.

25. The pacemaker of claim 19 wherein the controller is configured to automatically select the sensing vector prior to performing a threshold test for determining an appropriate pacing pulse energy for the pacemaker.

26. The pacemaker of claim 19 wherein the controller is configured to automatically select the sensing vector during a template acquisition routine in which a template representing biventricular capture is generated.