Biocompatible osteogenic band for repair of spinal disorders

• US 7,413,576 B2
• Filed: 05/20/2004
• Issued: 08/19/2008
• Est. Priority Date: 12/08/2000
• Status: Expired due to Fees

• Current Assignee: Warsaw Orthopedic Incorporated (Medtronic Plc)
• Original Assignee: Osteotech Incorporated (Medtronic Plc)
• Inventors: Shimp, Lawrence A., Boyle, John W., Sybert, Daryl R, Boyce, Todd M
• Primary Examiner(s): Gherbi; Suzette
• Application Number:
  US10/850,149
• Publication Number:
  US 20040215341A1
• Time in Patent Office: 1,552 Days
• Field of Search: 623 1311- 132, 623 1711- 1717, 606/61
• US Class Current: 623/13.17
• CPC Class Codes: A61B 17/7062 Devices acting on, attached to, or simulating the effect of, vertebral processes, vertebral facets or ribs rib fixation devices A61B17/8076; Tools for such devices
• CPC Class Codes: A61F 2/08 Muscles; Tendons; Ligaments sutures A61B17/04
• CPC Class Codes: A61F 2002/087 Anchor integrated into tendons, e.g. bone blocks, integrated rings
• CPC Class Codes: A61L 27/3604 characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
• CPC Class Codes: A61L 27/3608 Bone, e.g. demineralised bone matrix [DBM], bone powder
• CPC Class Codes: A61L 27/365 Bones
• CPC Class Codes: A61L 27/3658 Intervertebral discs mechanical aspects and structures of intervertebral discs A61F2/442
• CPC Class Codes: A61L 27/3683 subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
• CPC Class Codes: A61L 27/3856 Intervertebral discs mechanical aspects and structures of intervertebral discs A61F2/442

Abstract

Methods of repairing a joint formed by at least two bone sections are provided wherein a biocompatible osteogenic band fabricated from an osteogenic biological material such as bone, tendon, ligament and collagen is affixed to two or more bone sections.

Claims

1. A method for repairing a joint formed by at least two adjacent vertebrae, the method comprising:

providing a flexible biocompatible osteogenic band comprising a plurality of elongated sections, the band having a first end and a second end, and

affixing said first end of the biocompatible osteogenic band to one surface of a first vertebra and affixing said second end to a corresponding surface of a second vertebra, the first and second vertebrae being identical to, or encompassing, the adjacent vertebrae, to maintain the joint formed by the adjacent vertebrae under tension;

wherein the plurality of elongated sections of bone are braided or woven.

2. The method of claim 1, further comprising affixing said osteogenic band to at least one other vertebrae.

3. The method of claim 1, wherein at least one of the elongated sections comprises bone.

4. The method of claim 3, wherein the at least one elongated section comprises cortical bone.

5. The method of claim 3, wherein the at least one of the elongated section is demineralized.

6. The method of claim 5, wherein the at least one elongated section is chemically cross linked.

7. The method of claim 6, wherein the at least one of the elongated section is segmentally demineralized.

8. The method of claim 1, wherein the plurality of elongated sections of bone is demineralized.

9. The method of claim 1, wherein at least one of the first end or the second end is threaded.

10. The method of claim 9, wherein affixing said first end of the biocompatible osteogenic band to one surface of a first vertebra and affixing said second end to a corresponding surface of a second vertebra comprises threading the threaded first or second end.

11. The method of claim 1, wherein at least one of the first end or the second end comprises an attachment hole.

12. The method of claim 11, wherein affixing said first end of the biocompatible osteogenic band to one surface of a first vertebra and affixing said second end to a corresponding surface of a second vertebra comprises affixing through the attachment hole.

13. The method of claim 1, wherein at least one of the first end or the second end comprises a loop formed by the plurality of elongated sections of bone.

14. The method of claim 1, wherein affixing said first end of the biocompatible osteogenic band to one surface of a first vertebra and affixing said second end to a corresponding surface of a second vertebra comprises affixing at least one of the first end and the second end to a posterior side of a spine.

15. The method of claim 1, wherein affixing said first end of the biocompatible osteogenic band to one surface of a first vertebra and affixing said second end to a corresponding surface of a second vertebra comprises affixing the first end and the second end to posterior sites of a spine.

16. The method of claim 1, wherein said first end of said biocompatible osteogenic band is affixed to the pedicle, transverse process, mamillary process, inferior articular process, superior process, spinous process or accessory process of the first vertebrae and said second end of said biocompatible osteogenic band is affixed to the pedicle, transverse process, mamillary process, superior articular process spinous process or accessory process of the second vertebrae.

17. The method of claim 1, wherein at least one of the elongated sections comprises ligament tissue wherein the ligament tissue has been rendered osteogenic.

18. The method of claim 1, wherein the biocompatible osteogenic band has a dimension between about 1 cm and about 1 meter in length, between 2 mm and about 30 mm in thickness, and between about 2 mm and about 30 mm in width.

19. A method for repairing a joint formed by at least two adjacent vertebrae, the method comprising:

providing a flexible biocompatible osteogenic band comprising a plurality of elongated sections, the band having a first end and a second end,

affixing said first end of the biocompatible osteogenic band to one surface of a first vertebra and affixing said second end to a corresponding surface of a second vertebra, the first and second vertebrae being identical to, or encompassing, the adjacent vertebrae, to maintain the joint formed by the adjacent vertebrae under tension;

wherein at least one of the elongated sections comprises a synthetic biocompatible polymer or copolymer wherein the polymer or copolymer has been rendered osteogenic.

20. The method of claim 19, wherein said first end of said biocompatible osteogenic band is affixed to the pedicle, transverse process, mamillary process, inferior articular process, superior process, spinous process or accessory process of the first vertebrae and said second end of said biocompatible osteogenic band is affixed to the pedicle, transverse process, mamillary process, superior articular process spinous process or accessory process of the second vertebrae.

21. A method for repairing a joint formed by at least two adjacent vertebrae, the method comprising:

providing a flexible biocompatible osteogenic band comprising a plurality of elongated sections, the band having a first end and a second end,

affixing said first end of the biocompatible osteogenic band to one surface of a first vertebra and affixing said second end to a corresponding surface of a second vertebra, the first and second vertebrae being identical to, or encompassing, the adjacent vertebrae, to maintain the joint formed by the adjacent vertebrae under tension;

wherein at least one of the elongated sections comprises collagen tissue wherein the collagen tissue has been rendered osteogenic.

22. The method of claim 21, wherein said first end of said biocompatible osteogenic band is affixed to the pedicle, transverse process, mamillary process, inferior articular process, superior process, spinous process or accessory process of the first vertebrae and said second end of said biocompatible osteogenic band is affixed to the pedicle, transverse process, mamillary process, superior articular process spinous process or accessory process of the second vertebrae.

23. A method for repairing a joint formed by at least two adjacent vertebrae, the method comprising:

providing a flexible biocompatible osteogenic band comprising a plurality of elongated sections, the band having a first end and a second end,

affixing said first end of the biocompatible osteogenic band to one surface of a first vertebra and affixing said second end to a corresponding surface of a second vertebra, the first and second vertebrae being identical to, or encompassing, the adjacent vertebrae, to maintain the joint formed by the adjacent vertebrae under tension;

wherein at least one of the elongated sections comprises submucosa of the intestine wherein the submucosa has been rendered osteogenic.

24. The method of claim 23, wherein said first end of said biocompatible osteogenic band is affixed to the pedicle, transverse process, mamillary process, inferior articular process, superior process, spinous process or accessory process of the first vertebrae and said second end of said biocompatible osteogenic band is affixed to the pedicle, transverse process, mamillary process, superior articular process spinous process or accessory process of the second vertebrae.

25. A method for repairing a joint formed by at least two adjacent vertebrae, the method comprising:

providing a flexible biocompatible osteogenic band comprising a plurality of elongated sections, the band having a first end and a second end,

affixing said first end of the biocompatible osteogenic band to one surface of a first vertebra and affixing said second end to a corresponding surface of a second vertebra, the first and second vertebrae being identical to, or encompassing, the adjacent vertebrae, to maintain the joint formed by the adjacent vertebrae under tension;

wherein the plurality of elongated sections of bone are braided or woven.

26. The method of claim 25, wherein said first end of said biocompatible osteogenic band is affixed to the pedicle, transverse process, mamillary process, inferior articular process, superior process, spinous process or accessory process of the first vertebrae and said second end of said biocompatible osteogenic band is affixed to the pedicle, transverse process, mamillary process, superior articular process spinous process or accessory process of the second vertebrae.

27. A method for repairing a joint formed by at least two adjacent vertebrae, the method comprising:

providing a flexible biocompatible osteogenic band comprising a plurality of elongated sections, the band having a first end and a second end,

affixing said first end of the biocompatible osteogenic band to one surface of a first vertebra and affixing said second end to a corresponding surface of a second vertebra, the first and second vertebrae being identical to, or encompassing, the adjacent vertebrae, to maintain the joint formed by the adjacent vertebrae under tension; and

wherein the plurality of elongated sections of bone are twisted to form a single twisted bundle.

28. The method of claim 27, wherein said first end of said biocompatible osteogenic band is affixed to the pedicle, transverse process, mamillary process, inferior articular process, superior process, spinous process or accessory process of the first vertebrae and said second end of said biocompatible osteogenic band is affixed to the pedicle, transverse process, mamillary process, superior articular process spinous process or accessory process of the second vertebrae.

29. A method for repairing a joint formed by at least two adjacent vertebrae, the method comprising:

providing a flexible biocompatible osteogenic band comprising a plurality of elongated sections, the band having a first end and a second end,

affixing said first end of the biocompatible osteogenic band to one surface of a first vertebra and affixing said second end to a corresponding surface of a second vertebra, the first and second vertebrae being identical to, or encompassing, the adjacent vertebrae, to maintain the joint formed by the adjacent vertebrae under tension;

wherein the plurality of elongated sections of bone are bundled to form two or more bundles of multi-bone sections and wherein the multi-bone sections are wrapped to form a two or more bundle helix.

30. The method of claim 29, wherein said first end of said biocompatible osteogenic band is affixed to the pedicle, transverse process, mamillary process, inferior articular process, superior process, spinous process or accessory process of the first vertebrae and said second end of said biocompatible osteogenic band is affixed to the pedicle, transverse process, mamillary process, superior articular process spinous process or accessory process of the second vertebrae.

31. A method for repairing a joint formed by at least two adjacent vertebrae, the method comprising:

providing a flexible biocompatible osteogenic band comprising a plurality of elongated sections, the band having a first end and a second end,

affixing said first end of the biocompatible osteogenic band to one surface of a first vertebra and affixing said second end to a corresponding surface of a second vertebra, the first and second vertebrae being identical to, or encompassing, the adjacent vertebrae, to maintain the joint formed by the adjacent vertebrae under tension; and

wherein at least one of the first and second ends is sealed with a polymer.

32. The method of claim 31, wherein said first end of said biocompatible osteogenic band is affixed to the pedicle, transverse process, mamillary process, inferior articular process, superior process, spinous process or accessory process of the first vertebrae and said second end of said biocompatible osteogenic band is affixed to the pedicle, transverse process, mamillary process, superior articular process spinous process or accessory process of the second vertebrae.

33. A method for repairing a spinal disorder, the method comprising:

providing a biocompatible osteogenic band comprising a demineralized core and a weave of bioabsorbable fibers surrounding the core, the band having a first end and a second end, and

affixing said first end of the biocompatible osteogenic band to one surface of a first vertebra and affixing said second end to a corresponding surface of a second vertebra, the first and second vertebrae being identical to, or encompassing, the adjacent vertebrae, to maintain the joint formed by the adjacent vertebrae under tension.

34. The method of claim 33, wherein said first end of said biocompatible osteogenic band is affixed to the pedicle, transverse process, mamillary process, inferior articular process, superior process, spinous process or accessory process of the first vertebrae and said second end of said biocompatible osteogenic band is affixed to the pedicle, transverse process, mamillary process, superior articular process spinous process or accessory process of the second vertebrae.

35. The method of claim 33, wherein the bioabsorbable fibers comprise a synthetic biocompatible polymer and wherein the synthetic biocompatible polymer is rendered osteogenic.

36. The method of claim 33, wherein the weave of bioabsorbable fibers comprises demineralized bone strips.

37. The method of claim 33, wherein the core comprises a monolithic bone.

38. The method of claim 33, wherein the core is segmentally demineralized.