Ischemia detection based on cardiac conduction time

• US 7,415,307 B2
• Filed: 10/31/2002
• Issued: 08/19/2008
• Est. Priority Date: 10/31/2002
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Sharma, Vinod, Olson, Walter H.
• Primary Examiner(s): Layno; Carl H.
• Assistant Examiner(s): Gedeon; Brian T
• Application Number:
  US10/284,900
• Publication Number:
  US 20040088017A1
• Time in Patent Office: 2,119 Days
• Field of Search: 600/516, 600/509, 600/508, 607/17, 607/25
• US Class Current: 607/17
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: A61N 1/3629 in combination with non-electric therapy

Abstract

Methods and process for detection of myocardial ischemia involve detection and analysis of changes in electrical conduction velocity within the heart to monitor changes in the condition of the cardiac muscle and indicate possible ischemia. Conduction velocity slows considerably when oxygen supply to the heart is reduced. Analysis of electrical conduction velocity can be used to verify the occurrence of myocardial ischemia in a more reliable manner. Changes in conduction velocity may be monitored based on conduction time between electrodes positioned in the left and right ventricles of the heart. The electrodes may be endocardial or epicardial electrodes. In general, the techniques may involve launching a stimulation waveform at one electrode and sensing a local cardiac depolarization at another electrode to assess conduction time.

Claims

1. A method comprising:

detecting ST segment deviations via a wholly-implantable medical device (IMD);

detecting patient activity levels via the IMD;

detecting cardiac conduction time between at least a first pair and a second pair of fully implantable fixed electrodes which are all operatively coupled to an active implantable medical device (IMD), wherein said first pair and said second pair are separate pairs of fully-implantable electrodes; and

indicating myocardial ischemia based on each one of;

(i) changes in conduction time in combination with ST segment deviation, (ii) changes in conduction time in combination with a detected patient activity level, and (iii) the time rate of change of conduction time wherein conduction time is detected between said first pair and said second pair of fully implantable electrodes.

2. The method of claim 1, further comprising:

launching a stimulation wave front from a pair of first electrodes positioned proximate a first ventricular chamber; and

sensing a local cardiac depolarization at a pair of second electrodes positioned proximate a second ventricular chamber,

wherein detecting cardiac conduction time includes detecting a time between launching the wave front and sensing the local cardiac depolarization for each said pair of electrodes.

3. The method of claim 2, wherein the first electrode includes an endocardial electrode positioned within the first ventricular chamber, and the second electrode includes an epicardial electrode positioned on a surface of the second ventricular chamber.

4. The method of claim 2, wherein the first electrode includes an endocardial electrode positioned within the first ventricular chamber, and the second electrode includes an endocardial electrode positioned within the second ventricular chamber.

5. The method of claim 2, wherein the first electrode includes an epicardial electrode positioned on a surface of the first ventricular chamber, and the second electrode includes an epicardial electrode positioned on a surface of the second ventricular chamber.

6. The method of claim 2, wherein the first ventricular chamber is the right ventricular chamber and the second ventricular chamber is the left ventricular chamber.

7. The method of claim 2, wherein the first ventricular chamber is the left ventricular chamber and the second ventricular chamber is the right ventricular chamber.

8. The method of claim 1, further comprising detecting the conduction time using at least one lead associated with an implantable medical device.

9. The method of claim 1, further comprising quantifying a degree of ischemia based on the detected conduction time.

10. A device comprising:

a wholly-implantable medical device (IMD) including a detector to detect cardiac conduction time between a first pair and a second pair of fully implantable electrodes and a second pair of fully implantable electrodes, and indicate myocardial ischemia based on the detected conduction time of at least one of said first pair and second pair of fully implantable electrodes, wherein said detector includes;

means for comparing the detected conduction time of said first pair and said second pair to a respective threshold conduction time for said first pair and said second pair;

means for detecting ST segment deviation disposed within the IMD;

means for detecting patient activity level disposed within the IMD; and

means for indicating ischemia, also disposed within the IMD, based on each one of the following;

(i) changes in conduction time in combination with ST segment deviation, (ii) changes in conduction time in combination with a detected patient activity level, and (iii) the time rate of change of conduction time wherein conduction time is the detected conduction time between said first pair and said second pair of fully implantable electrodes.

11. The device of claim 10, further comprising:

a first electrode of said first pair of fully implantable electrodes positioned proximate a first ventricular chamber to launch a stimulation wave front; and

a second electrode of said first pair of fully implantable electrodes positioned proximate a second ventricular chamber to sense a local cardiac depolarization between said first electrode and said second electrode,

wherein the detector detects the cardiac conduction time based on a time between launching the wave front and sensing the local cardiac depolarization.

12. The device of claim 11, wherein the first electrode includes an endocardial electrode positioned within the first ventricular chamber, and the second electrode includes an epicardial electrode positioned on a surface of the second ventricular chamber.

13. The device of claim 11, wherein the first electrode includes an endocardial electrode positioned within the first ventricular chamber, and the second electrode includes an endocardial electrode positioned within the second ventricular chamber.

14. The device of claim 11, wherein the first electrode includes an epicardial electrode positioned on a surface of the first ventricular chamber, and the second electrode includes an epicardial electrode positioned on a surface of the second ventricular chamber.

15. The device of claim 11, wherein the first ventricular chamber is the right ventricular chamber and the second ventricular chamber is the left ventricular chamber.

16. The device of claim 11, wherein the first ventricular chamber is the left ventricular chamber and the second ventricular chamber is the right ventricular chamber.

17. The device of claim 10, wherein the detector senses the conduction time using at least one lead associated with an implantable medical device.

18. The device of claim 10, wherein the detector quantifies a degree of ischemia based on one of an average detected conduction time and the actual detected conduction time for a single conduction time measurement, wherein the average detected conduction time is derived from at least two discrete conduction time measurements.

19. A device comprising:

means for detecting cardiac conduction time between a first pair of fully implantable electrodes and between a second pair of fully implantable electrodes;

means for detecting ST segment deviation disposed within a wholly-implantable medical device (IMD);

means for detecting patient activity level disposed within the IMD; and

means for indicating myocardial ischemia, also disposed within the IMD, based on the detected conduction time of at least one of said first pair and said second pair of electrodes, wherein the means for indicating myocardial ischemia is based upon each one of;

(i) changes in conduction time in combination with ST segment deviation, (ii) changes in conduction time in combination with the detected patient activity level, (iii) the time rate of change of conduction time, and (iv) an average conduction time measurement derived from multiple conduction time measurements wherein conduction time is the detected conduction time between said first pair and said second pair of fully implantable electrodes.

20. The device of claim 19, further comprising:

a first electrode for launching a stimulation wave front from a first electrode positioned proximate a first ventricular chamber; and

a second electrode for sensing a local cardiac depolarization at a second electrode positioned proximate a second ventricular chamber,

wherein the detecting means detects a time between launching the wave front and sensing the local cardiac depolarization.

21. The device of claim 20, wherein the first electrode includes an endocardial electrode positioned within the first ventricular chamber, and the second electrode includes an epicardial electrode positioned on a surface of the second ventricular chamber.

22. The device of claim 20, wherein the first electrode includes an endocardial electrode positioned within the first ventricular chamber, and the second electrode includes an endocardial electrode positioned within the second ventricular chamber.

23. The device of claim 20, wherein the first ventricular chamber is the right ventricular chamber and the second ventricular chamber is the left ventricular chamber.

24. The device of claim 20, wherein the first ventricular chamber is the left ventricular chamber and the second ventricular chamber is the right ventricular chamber.

25. An apparatus, comprising:

means for detecting cardiac conduction time between at least a first pair and a second pair of fully implantable electrodes coupled to an active wholly-implantable medical device (IMD);

means for detecting ST segment deviation disposed within the IMD;

means for detecting patient activity level disposed within the IMD; and

means for indicating myocardial ischemia, also disposed within the IMD, based on each one of;

(i) changes in conduction time in combination with ST segment deviation, (ii) changes in conduction time in combination with the detected patient activity level, and (iii) the time rate of change of conduction time, and wherein conduction time is the detected conduction time between said first pair and said second pair of fully implantable electrodes.

26. An apparatus according to claim 25, further comprising:

means for launching a stimulation wave front from a first electrode adapted to be positioned proximate a first ventricular chamber; and

means for sensing a local cardiac depolarization at a second electrode adapted to be positioned proximate a second ventricular chamber,

and wherein the means for detecting cardiac conduction time includes means for detecting a time between launching the wave front and sensing the local cardiac depolarization.

27. An apparatus according to claim 26, wherein the first electrode comprises an endocardial electrode adapted to be positioned within the first ventricular chamber, and the second electrode comprises an epicardial electrode adapted to be positioned on a surface of the second ventricular chamber.

28. An apparatus according to claim 26, wherein the first electrode comprises an endocardial electrode adapted to be positioned within the first ventricular chamber, and the second electrode comprises an endocardial electrode adapted to be positioned within the second ventricular chamber.

29. An apparatus according to claim 26, wherein the first electrode comprises an epicardial electrode adapted to be positioned on a surface of the first ventricular chamber, and the second electrode comprises an epicardial electrode adapted to be positioned on a surface of the second ventricular chamber.

30. An apparatus according to claim 26, wherein the first ventricular chamber comprises a right ventricular chamber and the second ventricular chamber comprises a left ventricular chamber.

31. An apparatus, according to claim 26, wherein the first ventricular chamber comprises a left ventricular chamber and the second ventricular chamber comprises a right ventricular chamber.

32. An apparatus according to claim 25, further comprising:

means for detecting the conduction time using at least one lead associated with an implantable medical device.

33. An apparatus according to claim 25, further comprising:

means for quantifying a degree of ischemia based on the detected conduction time.