Tissue patches and related delivery systems and methods

• US 7,416,546 B2
• Filed: 11/14/2003
• Issued: 08/26/2008
• Est. Priority Date: 05/05/2003
• Status: Expired due to Fees

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Geitz, Kurt, Pugsley, Charles H., McBride-Sakal, Marcia
• Primary Examiner(s): Lucchesi; Nicholas D.
• Assistant Examiner(s): KOHARSKI, CHRISTOPHER
• Application Number:
  US10/706,965
• Publication Number:
  US 20040225247A1
• Time in Patent Office: 1,747 Days
• Field of Search: 606/213, 606/151, 606/154, 424/422, 424425-426, 424/93.1, 424/93.7, 424/93.2, 424/443, 424/447, 604/890.1, 604/500, 623/14.13, 623/15.11
• US Class Current: 604/500
• CPC Class Codes: A61F 13/00063 comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic drug delivery dressings A61K9/70; chemical aspect of the additives A61L15/00
• CPC Class Codes: A61F 13/0213 the fluid retention member being a layer of hydrocolloid, gel forming material
• CPC Class Codes: A61F 13/0226 characterised by the support layer
• CPC Class Codes: A61F 13/0253 characterized by the adhesive material
• CPC Class Codes: A61L 15/40 containing ingredients of undetermined constitution or reaction products thereof , e.g. plant or animal extracts
• CPC Class Codes: A61L 15/64 specially adapted to be resorbable inside the body

Abstract

Endoluminally delivered tissue patches and related systems and methods for delivering the tissue patches for treating lesions of the alimentary tract are disclosed. A tissue patch includes a substrate, a tissue implant attached to the substrate, and a protective liner covering at least a portion of the tissue implant. A method includes providing a tissue patch having a tissue implant attached to a substrate and a protective liner covering at least a portion of the tissue implant. The tissue patch is formed into a contracted state and inserted into a lumen containing the lesion. The tissue patch then is positioned in the vicinity of the lesion. After removing the protective liner to reveal the tissue implant, the tissue implant is placed in the lesion.

Claims

1. A method of treating a lesion in a nonvascular lumen of patient'"'"'s body, comprising:

providing a tissue patch having a tissue implant attached to a substrate and a protective liner covering at least a portion of the tissue implant;

forming the tissue patch into a contracted state;

inserting the tissue patch in the contracted state into a lumen containing the lesion;

positioning the tissue patch in the vicinity of the lesion;

removing the protective liner to reveal the tissue implant;

and placing the tissue implant in the lesion.

2. A method according to claim 1, further comprising placing the tissue patch on a portion of a catheter for inserting the tissue patch in the contracted state.

3. A method according to claim 1, further comprising expanding the tissue patch from the contracted state before the step of removing the protective liner.

4. A method according to claim 1, wherein an adhesive material is provided on the substrate and the protective liner attaches to the adhesive material.

5. A method according to claim 1, wherein at least a portion of the substrate includes an adhesive material.

6. A method according to claim 1, wherein the tissue implant is placed on a surface of the substrate.

7. A method according to claim 1, wherein the tissue implant is embedded in the substrate in a form of a cellular suspension.

8. A method according to claim 1, wherein the substrate is a bio-absorbable gel.

9. A method according to claim 1, further comprising attaching a carrier to the substrate on a surface opposite to the surface facing the lesion and removing the carrier from the substrate after the tissue implant is placed in the lesion.

10. A method according to claim 1, wherein the tissue implant is an engineered tissue.

11. A method according to claim 1, wherein forming the tissue patch into a contracted state includes folding the tissue patch.

12. A method according to claim 1, wherein forming the tissue patch into a contracted state includes rolling the tissue patch into a cylindrical shape.

13. A method according to claim 1, wherein the implant of tissue comprises a sheet of tissue.