Drug-eluting stent cover and method of use
First Claim
1. A stent system for delivery of a therapeutic agent in a body lumen, comprising:
- a stent configured to contact the wall of the body lumen to maintain the patency of the lumen; and
a stent cover, the stent cover defining a delivery sheath fabricated from a mesh and placed over the stent, wherein the mesh has a random configuration, wherein the delivery sheath contains at least one therapeutic agent in sufficient quantities for the release thereof at the treatment site, at least a portion of the mesh being configured to neck down in response to a radial outward directed force due to radial expansion of the stent, wherein the therapeutic agent loading range is about 30 to 60 percent by weight.
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Accused Products
Abstract
An intravascular stent includes an eluting sheath fabricated from a mesh for controlled release of therapeutic drugs and for delivery of the therapeutic drugs in localized drug therapy in a blood vessel. The eluting sheath is attached to at least a portion of an outside surface area of the stent structure and is fabricated from a mesh designed to neck down in response to a radially outward directed force resulting in the uniform expansion of the stent. The eluting sheath can be loaded with at least one therapeutic drug for the release thereof at a treatment site to facilitate repair of a damaged vessel. The stent has a high degree of flexibility in the longitudinal direction, yet has adequate vessel wall coverage and radial strength sufficient to hold open an artery or other body lumen.
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Citations
24 Claims
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1. A stent system for delivery of a therapeutic agent in a body lumen, comprising:
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a stent configured to contact the wall of the body lumen to maintain the patency of the lumen; and a stent cover, the stent cover defining a delivery sheath fabricated from a mesh and placed over the stent, wherein the mesh has a random configuration, wherein the delivery sheath contains at least one therapeutic agent in sufficient quantities for the release thereof at the treatment site, at least a portion of the mesh being configured to neck down in response to a radial outward directed force due to radial expansion of the stent, wherein the therapeutic agent loading range is about 30 to 60 percent by weight. - View Dependent Claims (2)
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3. A stent system for delivery of a therapeutic agent in a body lumen, comprising:
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a stent configured to contact the wall of the body lumen to maintain the patency of the lumen; and a stent cover, the stent cover defining a delivery sheath fabricated from a mesh and placed over the stent, wherein the mesh has a random configuration, wherein the delivery sheath contains at least one therapeutic agent in sufficient quantities for the release thereof at the treatment site, at least a portion of the mesh being configured to neck down in response to a radial outward directed force due to radial expansion of the stent, wherein the stent cover is attached to the stent at a stent distal end and a stent proximal end so that the cover is free to stretch in a mid-cover section as the stent expands.
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4. A stent system for delivery of a therapeutic agent in a body lumen, comprising:
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a stent configured to contact the wall of the body lumen to maintain the patency of the lumen; and a stent cover, the stent cover defining a delivery sheath fabricated from a mesh and placed over the stent, wherein the mesh stent cover is configured of a random mesh, wherein the delivery sheath contains at least one therapeutic agent in sufficient quantities for the release thereof at the treatment site, at least a portion of the mesh being configured to neck down in response to a radial outward directed force due to radial expansion of the stent, wherein the mesh stent cover is fabricated from a polymeric material selected from the group consisting of PMMA, EVAL, PBMA, PGA, PEG, HA, PEA, PGS and PLLA.
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5. A stent system for delivery of a therapeutic agent in a body lumen, comprising:
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a stent structure comprising a pattern of interconnected struts that contacts the wall of the body lumen to maintain the patency of the lumen; and a stent cover defining a delivery sheath fabricated as a metallic or ceramic prepatterned sheet having a polymer layer disposed thereon, the stent cover being loaded with at least one therapeutic agent for the release thereof at a treatment site, the stent cover being attached to at least a portion of an outside surface area of the stent structure. - View Dependent Claims (6, 7, 8, 9)
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10. A stent system for delivery of a therapeutic agent in a blood vessel, comprising:
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a pattern of struts interconnected to form a stent structure that contacts the wall of a body lumen to maintain the patency of the lumen; and a stent cover defining a delivery sheath fabricated from a mesh with a web pattern placed over the stent being attached to at least a portion of an outside surface area of the stent structure, the delivery sheath contains at least one therapeutic agent in sufficient quantities for the release thereof in the vessel, wherein the web pattern includes weakened points at selected locations to provide nonrandom breakage during expansion, the mesh cover being held against the lumen wall by the stent structure. - View Dependent Claims (11, 12, 13, 14)
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15. A stent system for deployment in a blood vessel, comprising:
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an intravascular stent configured to contact the walls of a vessel to maintain the patency of the vessel; and a stent cover defining a sheath fabricated from a mesh placed over the stent, the stent cover includes one or more positions that will break during expansion in a vessel.
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16. A drug-containing stent system for deployment in a body lumen, comprising:
a mesh structure containing at least one drug, the mesh structure including individual mesh members, at least one individual mesh member including a breakable point that will break during expansion to allow unbroken mesh members to deploy against a body lumen as the mesh further expands. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24)
Specification