Composition for an injectable bone mineral substitute material
First Claim
1. A composition for a bone mineral substitute material comprising a dry powder, the dry powder comprising a first setting reaction component, which is a calcium sulphate hemihydrate;
- a second setting reaction component, which is a calcium phosphate; and
at least one particulate accelerator for the setting reaction of both the first and the second setting reaction components, wherein the at least one accelerator for the reaction of the first setting reaction component is particulate calcium sulphate dihydrate, and the at least one accelerator for the reaction of the second setting reaction component is hardened particulate calcium phosphate cement.
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Abstract
The invention refers to an injectable composition for a bone mineral substitute material, which comprises a dry powder mixed with an aqueous liquid. The powder comprises a first reaction component comprising a calcium sulphate hemihydrate with the capability of being hardened to calcium sulphate dihydrate when reacting with said aqueous liquid; a second reaction component, which comprise a calcium phosphate with the capability of being hardened to a calcium phosphate cement when reacting with said aqueous liquid; and at least one accelerator for the reaction of said first and/or second reaction component with said aqueous liquid. A method of producing an injectable bone mineral substitute material is also provided, wherein the composition is mixed in a closed mixing and delivery system for delivery.
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Citations
45 Claims
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1. A composition for a bone mineral substitute material comprising a dry powder, the dry powder comprising a first setting reaction component, which is a calcium sulphate hemihydrate;
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a second setting reaction component, which is a calcium phosphate; and at least one particulate accelerator for the setting reaction of both the first and the second setting reaction components, wherein the at least one accelerator for the reaction of the first setting reaction component is particulate calcium sulphate dihydrate, and the at least one accelerator for the reaction of the second setting reaction component is hardened particulate calcium phosphate cement. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 38, 39, 40, 41, 42, 43)
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26. A composition for a bone mineral substitute material comprising a dry powder, the dry powder comprising
a first setting reaction component, which is a calcium sulphate hemihydrate; -
a second setting reaction component, which is a calcium phosphate; at least one accelerator for the setting reaction of the first or second setting reaction component, or both the first and the second setting reaction components, wherein the at least one accelerator is chosen from at least one accelerator for the reaction of the first setting reaction component, wherein the accelerator is particulate calcium sulphate dihydrate, and the at least one accelerator for the reaction of the second setting reaction component, wherein the accelerator is hardened particulate calcium phosphate cement; and a biologically compatible oil to improve the injectability of the composition. - View Dependent Claims (27, 28, 29, 30, 31)
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32. A composition for a bone mineral substitute material comprising
a dry powder, the dry powder comprising a first setting reaction component, which is a calcium sulphate hemihydrate; -
a second setting reaction component, which is a calcium phosphate; at least one accelerator for the setting reaction of the first or the second setting reaction component, or both the first and the second setting reaction components, wherein the at least one accelerator is chosen from at least one accelerator for the reaction of the first setting reaction component, the accelerator being a particulate calcium sulphate dihydrate, and at least one accelerator for the reaction of the second setting reaction component, the accelerator being a hardened particulate calcium phosphate cement; and a pH reducing component to improve the injectability of the composition. - View Dependent Claims (33, 34, 35, 36, 37)
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44. A composition for a bone mineral substitute material comprising a dry powder, the dry powder comprising a first setting reaction component, which is a calcium sulphate hemihydrate;
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a second setting reaction component, which is a calcium phosphate; and at least one particulate accelerator for the setting reaction of both the first and the second setting reaction components, wherein the at least one accelerator for the reaction of the first setting reaction component is particulate calcium sulphate dihydrate, and the at least one accelerator for the reaction of the second setting reaction component is hardened particulate calcium phosphate cement, wherein the calcium sulphate dihydrate comprises 0.1 wt % to 10 wt % of the first reaction component. - View Dependent Claims (45)
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Specification