Apparatus and method for adjustment of ion separation resolution in FAIMS
First Claim
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1. An apparatus for separating ions, comprising:
- a FAIMS analyzer region having a first ion inlet for introducing ions into the FAIMS analyzer region and having an ion outlet for extracting a subset of the ions that is selectively transmitted along an average ion flow path defined through the FAIMS analyzer region; and
,a controller for controllably varying a length of an average ion flow path through the FAIMS analyzer region.
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Abstract
An apparatus for separating ions includes a FAIMS analyzer region having a first ion inlet for introducing ions into the FAIMS analyzer region. An ion outlet from the FAIMS analyzer region is provided for extracting a subset of the ions that is selectively transmitted along an average ion flow path defined through the FAIMS analyzer region. The apparatus also includes an actuator for controllably varying a length of the average ion flow path through the FAIMS analyzer region.
22 Citations
31 Claims
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1. An apparatus for separating ions, comprising:
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a FAIMS analyzer region having a first ion inlet for introducing ions into the FAIMS analyzer region and having an ion outlet for extracting a subset of the ions that is selectively transmitted along an average ion flow path defined through the FAIMS analyzer region; and
,a controller for controllably varying a length of an average ion flow path through the FAIMS analyzer region. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. A method for separating ions, comprising:
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providing a FAIMS analyzer region having a first ion inlet for introducing ions thereto and having an ion outlet for extracting a subset of the ions that is selectively transmitted along an average ion flow path through the FAIMS analyzer region; introducing ions into the FAIMS analyzer region via the first ion inlet; selectively transmitting a subset of the ions through the FAIMS analyzer region along a first length of an average ion flow path; changing an average ion flow path length through the FAIMS analyzer region; and
,transmitting ions along the second length of an average ion flow path. - View Dependent Claims (24, 25, 26, 27)
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28. A method for separating ions, comprising:
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providing a FAIMS analyzer region having an ion inlet end for receiving ions and having an ion outlet for providing a subset of the ions that is selectively transmitted between the ion inlet end and the ion outlet of the FAIMS analyzer region; defining a first average ion flow path length through the FAIMS analyzer region; defining a second average ion flow path length through the FAIMS analyzer region, the second average ion flow path length different than the first average ion flow path length; and
,controllably switchably providing ions along the first average ion flow path length and the second average ion flow path length. - View Dependent Claims (29, 30)
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31. An apparatus for separating ions, comprising:
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a FAIMS analyzer region controllably switchable between a low specificity mode of operation and a high specificity mode of operation and defined by at least a space between a plurality of spaced-apart electrode surfaces, the FAIMS analyzer region in communication with an ionization source for providing a flow of ions including a known ion, and with an ion outlet for extracting ions including the known ion from the FAIMS analyzer region; and
,a controller for controllably switching the FAIMS analyzer region between the low specificity mode of operation and the high specificity mode of operation.
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Specification