Polymer coating for medical devices

• US 7,419,709 B2
• Filed: 11/28/2006
• Issued: 09/02/2008
• Est. Priority Date: 02/15/2002
• Status: Expired due to Fees

• Current Assignee: CV Therapeutics Inc (Gilead Sciences Inc.)
• Original Assignee: CV Therapeutics Inc (Gilead Sciences Inc.)
• Inventors: Rypacek, Frantisek, Machova, Ludka, Lapcikova, Monika
• Primary Examiner(s): Chevalier; Alicia
• Assistant Examiner(s): Bruenjes; Christopher P
• Application Number:
  US11/605,654
• Publication Number:
  US 20070071926A1
• Time in Patent Office: 644 Days
• Field of Search: 428/36.9, 428/36.91, 428/447, 428/448, 428/450, 428/480, 424422-426, 623/1.38, 623/1.42, 623/1.43, 623/1.44, 623/1.46, 604/890.1, 604/891.1
• US Class Current: 428/36.9
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61L 33/0076 Chemical modification of the substrate
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence
• CPC Class Codes: C08L 83/04 Polysiloxanes
• CPC Class Codes: Y10T 428/1352 Polymer or resin containing [i.e., natural or synthetic]
• CPC Class Codes: Y10T 428/139 Open-ended, self-supporting conduit, cylinder, or tube-type article
• CPC Class Codes: Y10T 428/1393 Multilayer [continuous layer]
• CPC Class Codes: Y10T 428/31663 As siloxane, silicone or silane
• CPC Class Codes: Y10T 428/31786 Of polyester [e.g., alkyd, etc.]

Abstract

Coatings are provided in which surfaces may be activated by covalently bonding a silane derivative to the metal surface, covalently bonding a lactone polymer to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of a polyester on the bonded lactone. Biologically active agents may be deposited with the polyester layers. Such coated surfaces may be useful in medical devices, in particular stents.

Claims

1. A method of reducing cell prolitbration in a mammal comprising providing to the mammal a medical device having a coating over a body fluid-contacting surface of the medical device for contacting blood, other body fluids and the like, wherein the coating comprises:

a silane derivative layer covalently bonded to the body fluid-contacting surface of the medical device, said silane derivative layer containing hydroxyl or amino functional groups;

lactone polymer chains grown on the hydroxyl or amino functional groups of the silane derivative through in-situ ring opening graft polymerization of lactone monomers, said polymerization initiated by said hydroxyl or amino functional groups of the silane derivative covalently bonded to the surface of the medical device, said lactone polymer chains and said silane derivative together forming a grafted lactone polymer layer; and

at least one polyester polymer/biologically active agent layer deposited on the grafted lactone polymer layer, wherein at least the first of the deposited polymer/biologically active agent layers is chemically compatible with the grafted lactone polymer layer to allow for entanglement of said deposited polyester polymer chains with the chains of said grafted lactone polymer chains for strong adhesion.

2. The method of claim 1 wherein the device further comprises from about 0.5% to about 60% by weight of one or more biologically active agents.

3. The method of claim 1 wherein the medical device is a stent.

4. The method of claim 2 wherein the biologically active agent is an anti-proliferative.

5. The method of claim 4 wherein the biologically active agent is a CDK2 inhibitor.