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Mass spectrometric methods for detecting mutations in a target nucleic acid

DC
  • US 7,419,787 B2
  • Filed: 05/11/2006
  • Issued: 09/02/2008
  • Est. Priority Date: 03/17/1995
  • Status: Expired due to Fees
First Claim
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1. A process for detecting one or more target nucleotide sequences in a biological sample, comprising:

  • a) amplifying a target nucleic acid molecule, wherein the amplification product is a natural nucleic acid;

    b) ionizing and volatilizing the product of step (a); and

    c) analyzing the product of step (b) by mass spectrometry, wherein detection of the target nucleotide sequence by mass spectrometry indicates the presence of the target nucleotide sequence in the biological sample.

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