Sensing photon energies of optical signals

• US 7,420,677 B2
• Filed: 12/22/2005
• Issued: 09/02/2008
• Est. Priority Date: 12/22/2005
• Status: Active Grant

• Current Assignee: Xerox Corporation (Xerox Holdings Corp.)
• Original Assignee: Palo Alto Research Center, Inc. (Xerox Holdings Corp.)
• Inventors: Kiesel, Peter, Johnson, Noble M., Maeda, Patrick Y., Schmidt, Oliver
• Primary Examiner(s): EVANS, FANNIE L
• Application Number:
  US11/315,926
• Publication Number:
  US 20070147189A1
• Time in Patent Office: 985 Days
• Field of Search: 356/317, 356/417, 356/416, 356/419
• US Class Current: 356/417
• CPC Class Codes: B01L 3/5027 by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip B01L3/5023 takes precedence; micromixers B01F33/30; microreactors for synthesis B01J19/0093; microcapillary devices in general B81B1/00
• CPC Class Codes: G01J 2003/1213 Filters in general, e.g. dichroic, band
• CPC Class Codes: G01J 3/26 using multiple reflection, e.g. Fabry-Perot interferometer, variable interference filters
• CPC Class Codes: G01J 3/2803 using photoelectric array detector
• CPC Class Codes: G01N 2021/6482 Sample cells, cuvettes
• CPC Class Codes: G01N 21/645 Specially adapted constructive features of fluorimeters

Abstract

An integrated circuit includes a photosensor array with subrange cells that photosense within respective subranges of an energy range. An optical signal and the array move relative to each other, and, for segments of their relative movement, sets of subrange cells photosense within subranges that are different. For example, a scanning device can cause relative scanning movement. The optical signal can be produced by illuminating a two-dimensional object. The photosensed quantities for a part of the optical signal can be used to produce spectral information for the part.

Claims

1. A method of sensing line-like optical signals, the method comprising:

obtaining a line-like optical signal;

causing relative scanning movement between the line-like optical signal and a two-dimensional photosensor array included in an integrated circuit (IC), the optical signal including photons within an application'"'"'s range of photon energies;

the optical signal following a scan path across the array along which cells in the array photosense photons in the optical signal;

the scan path extending in a relative movement direction;

the line-like optical signal extending in a direction approximately perpendicular to the relative movement direction; and

in each of two or more segments of the scan path, using a respective line of one or more cells in the array to photosense quantities of photons in the optical signal;

each segment'"'"'s respective line of cells including at least one cell that photosenses photons within a respective subrange of the range of photon energies;

the respective subranges of at least two of the segments being different from each other;

the act of obtaining the line-like optical signal comprising at least one of;

illuminating a two-dimensional object with line-like illumination to obtain the line-like optical signal;

using a line-like aperture to obtain the line-like optical signal from a two-dimensional optical signal; and

using an optical component to prevent the line-like optical signal from spreading in the relative movement direction.

2. The method of claim 1 in which a part of the optical signal follows a line-like path across the array, the method further comprising:

using quantities photosensed by the respective lines of cells of at least two of the segments as the part of the optical signal follows the line-like path to produce signals indicating spectral information about photons from the part of the optical signal.

3. The method of claim 2 in which the respective subranges of the segments span substantially the entire range of photon energies, the signals indicating a complete spectral distribution of photons from the part of the optical signal.

4. The method of claim 1 in which the act of obtaining the line-like optical signal comprises both of:

illuminating the two-dimensional object with line-like illumination to obtain the line-like optical signal; and

using the optical component to prevent the line-like optical signal from spreading in the relative movement direction.

5. The method of claim 1 in which the act of obtaining the line-like optical signal comprises both of:

using the line-like aperture to obtain the line-like optical signal from the two-dimensional optical signal; and

using the optical component to prevent the line-like optical signal from spreading in the relative movement direction.

6. The method of claim 1 in which the:

optical component includes at least one of a lens, a lens array, or a GRIN lens.

7. The method of claim 1 in which the act of obtaining the optical signal further comprises:

obtaining the optical signal from reflected, transmitted, or fluoresced light.

8. The method of claim 1 in which the act of causing relative scanning movement includes at least one of moving the optical signal and moving the IC.

9. Apparatus comprising:

an integrated circuit (IC) that includes a photosensor array;

the array including cells that photosense quantities of photons received;

a scanning device that produces relative scanning movement between an optical signal and the photosensor array, the optical signal including photons within an application'"'"'s range of photon energies;

the optical signal following a scan path across the array along which cells in the array photosense photons in the optical signal;

each of a set of one or more parts of the optical signal having a respective distribution of photon energies within the application'"'"'s range and following a respective line-like path across the array;

a transmission structure that receives the optical signal along at least part of the scan path and, in response, provides photons to the photosensor array such that, in each of two or more segments of the scan path, a respective set of one or more cells in the array photosenses quantities of photons in the optical signal;

each segment'"'"'s respective set of cells including at least one cell that photosenses photons within a respective subrange of the range of photon energies;

the respective subranges of at least two of the segments being different from each other; and

circuitry that uses quantities photosensed by the respective cells of at least two of the segments as one of the set of parts follows its line-like path to obtain spectral information about the one part'"'"'s respective distribution of photon energies.

10. The apparatus of claim 9,

in which the transmission structure has a series of regions, each region transmitting photons from the optical signal in a respective segment of the scan path to a respective subset of the cells, each region transmitting to its respective subset of the cells photons within a respective subrange of the range of photon energies;

the respective subranges of at least two of the regions being different.

11. The apparatus of claim 10 in which the transmission structure includes a coating that varies continuously along the scan path, each region in the series of regions including a respective area of the coating.

12. The apparatus of claim 11 in which the coating is over the photosensor array.

13. The apparatus of claim 9

in which the circuitry further provides signals indicating the spectral information.

14. The apparatus of claim 9 in which the IC includes a CCD or CMOS photosensor array.

15. The apparatus of claim 9 in which the scanning device provides a scanning motion between a two-dimensional object and the photosensor array, the optical signal being obtained by illuminating the two-dimensional object.

16. A system that comprises the apparatus of claim 9, the system further comprising:

a processor connected to control the scanning device and to read out photosensed quantities of photons from the photosensor array.

17. The system of claim 16 in which the system further comprises a light source that illuminates two-dimensional objects;

in response to the processor, the scanning device causing relative scanning movement between an illuminated two-dimensional object and the photosensor array so that an optical signal from the two-dimensional object travels along a scan path across the array;

in response to the processor, the sets of cells photosensing quantities of photons in the optical signal.

18. A method comprising:

producing apparatus as in claim 9;

the act of producing apparatus including;

producing the apparatus to include;

the IC that includes the photosensor array;

the scanning device that produces relative scanning movement between the optical signal and the photosensor array, the optical signal following the scan path across the array;

the transmission structure; and

the circuitry; and

producing the apparatus so that each of two or more segments of the scan path has a respective set of one or more cells in the array photosensing quantities of photons in the optical signal;

each segment'"'"'s respective set of cells including at least one cell that photosenses photons within a respective subrange of the range of photon energies;

the respective subranges of at least two of the segments being different from each other.

19. A method comprising:

receiving an optical signal at a photosensor array included in an integrated circuit (IC), the optical signal including photons within an application'"'"'s range of photon energies;

the received optical signal and the array moving relative to each other along a first direction;

in each of two or more segments of the first direction, using a respective set of one or more cells in the array to photosense quantities of photons in the optical signal;

each segment'"'"'s respective set of cells photosensing photons within a respective subrange of the range of photon energies;

the respective subranges of at least two of the segments being different from each other; and

for each of a set of one or more parts of the optical signal, combining quantities photosensed by the respective sets of cells of two or more of the segments to obtain spectral information for the part of the optical signal.

20. The method of claim 19, further comprising:

providing relative scanning movement between the received optical signal and the array.

21. The method of claim 19 in which the respective subranges of the segments span substantially the entire range of photon energies, the act of combining quantities producing a complete spectral distribution for the part of the optical signal.

22. The method of claim 19 in which the optical signal emanates from a point-like source or is a line-like or two-dimensional optical signal.

23. The method of claim 19, further comprising:

obtaining the optical signal from a two-dimensional object.

24. The method of claim 19 in which the optical signal is two-dimensional, the method further comprising:

using an optical component to image the two-dimensional optical signal on the array, the optical component including at least one of a lens, a lens array, or a GRIN Lens-like.

25. The method of claim 23 in which the two-dimensional object is a sheet-like medium, an array of wells, or a biochip.

26. The method of claim 23 in which the two-dimensional object is a sheet-like medium and the act of obtaining the optical signal comprises:

illuminating the sheet-like medium to obtain the optical signal from reflected light.

27. The method of claim 23 in which the two-dimensional object is an array of wells disposed toward a forward side and the act of obtaining the optical signal comprises:

illuminating the array of wells from the forward side or from a back side opposite the forward side to obtain the optical signal.

28. The method of claim 23 in which the two-dimensional object is a fluidic structure with a channel containing an analyte and the act of obtaining the optical signal comprises:

providing excitation to the fluidic structure to cause the analyte to fluoresce.

29. The method of claim 28 in which the two-dimensional object is a biochip and the channel contains fluid;

the act of providing excitation illuminating the channel to cause anti-resonant waveguiding.

30. The method of claim 23 in which the act of obtaining the optical signal comprising:

causing relative scanning movement between the two-dimensional object and an assembly of components, the assembly of components including an illumination source.

31. The method of claim 19 in which the respective sets of cells of the segments are distinct, with no shared cells.

32. Apparatus comprising:

an assembly including;

a two-dimensional photosensor array; and

a transmission structure;

a scanning device that produces relative scanning movement in a relative movement direction between an optical signal and the assembly, the optical signal including photons within an application'"'"'s range of photon energies;

the optical signal following a scan path across the array along which cells in the array photosense photons in the optical signal;

the transmission structure receiving the optical signal along at least part of the scan path and, in response, providing photons to the photosensor array such that, in each of two or more segments of the scan path, a respective set of one or more cells in the array photosenses quantities of photons from the transmission structure;

each segment'"'"'s respective set of cells extending in an orthogonal direction perpendicular to the relative movement direction and including at least one cell that photosenses photons within a respective subrange of the range of photon energies;

the respective subranges of at least two of the segments being different from each other; and

an optical component that receives the optical signal and provides it to the transmission structure;

the optical component performing at least one of;

preserving resolution of the optical signal in the relative movement direction;

preserving resolution of the optical signal in the orthogonal direction; and

imaging the optical signal onto the photosensor array.

33. The apparatus of claim 32 in which the optical component includes at least one of:

a lens;

a lens array; and

GRIN lens.