Microabrader with controlled abrasion features

• US 7,422,567 B2
• Filed: 08/27/2003
• Issued: 09/09/2008
• Est. Priority Date: 08/29/2002
• Status: Active Grant

• Current Assignee: Becton, Dickinson & Co
• Original Assignee: Becton, Dickinson & Co
• Inventors: Clarke, Richard P., Martin, Frank E., Haider, M. Ishaq, Alarcon, Jason B., Harding, Weston, Mikszta, John A., Lastovich, Alexander G., Dekker, John P. III
• Primary Examiner(s): Lucchesi; Nicholas D.
• Assistant Examiner(s): Stigell; Theodore J
• Application Number:
  US10/649,395
• Publication Number:
  US 20040064087A1
• Time in Patent Office: 1,840 Days
• Field of Search: 604 46- 48, 606167-173, 606/180
• US Class Current: 604/46
• CPC Class Codes: A61B 17/205 Vaccinating by means of needles or other puncturing devices
• CPC Class Codes: A61B 2017/320004 abrasive
• CPC Class Codes: A61M 2037/0007 having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
• CPC Class Codes: A61M 2037/0023 Drug applicators using microneedles
• CPC Class Codes: A61M 2037/0038 having a channel at the side surface
• CPC Class Codes: A61M 2037/0046 Solid microneedles
• CPC Class Codes: A61M 2037/0053 Methods for producing microneedles
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: A61M 37/0015 by using microneedles

Abstract

An abrader device for delivering a substance into skin via an abrasion process includes a housing adapted to be pressed against the skin at a desired delivery site, an applicator head disposed in an upper opening of the housing and movable across a lower opening of the housing to abrade the delivery site in at least one furrow, and an abrader surface attached to the applicator head whereby the housing remains firm and stationary at the delivery site and structure of the housing and the applicator head controls parameters of the abrasion process. In particular, the amount of force or pressure applied to the abrader surface, the speed at which the abrader surface moves across the skin and the number of lateral passes of the abrader surface across the skin are controlled so that the abrader device provides a furrow with a length of substantially the same depth thereby providing reproducible results, even though different technicians are applying the abrader device against a patient'"'"'s skin.

Claims

1. An abrader device for delivering a substance into skin via an abrasion process, said abrader device comprising:

a base having a top surface and a bottom surface onto which an abrader surface with microprotrusions is mounted, said microprotrusions are frustroconical protrusions and each protrusion having at least one scraping edge for forming a furrow along a length of the skin;

a housing surrounding the base;

a handle having a pushbutton projecting from a top surface of the device;

wherein said pushbutton has a first detent, wherein said first detent is engagable with a cooperating detent on said base and said detents cooperate to prevent inadvertent movement of said handle with respect to said base wherein said first detent of said pushbutton and said detent on said base hold the pushbutton in a substantially extended position prior to use wherein the pushbutton collapses inside the base when activated, and the base rotates with respect to the housing and proportionally to the push button collapse, thereby causing the abrader surface to rotate against skin when the housing is placed against skin and

a spring operably engaged between the handle and the base, wherein movement of the handle causes proportional compression of the spring for controlling the amount of force or pressure applied to the microprotrusions as the abrader surface moves across the skin thereby forming a furrow of a substantially consistent depth along its length.

2. The abrader device according to claim 1, wherein the microprotrusions are of a depth of about 5 to about 250 microns.

3. The abrader device according to claim 1, wherein said spring is a preloaded spring that deflects only if a sufficient amount of pressure is present, and further comprising a retention detent on said base that engages a portion of said pushbutton after said push button has been fully depressed wherein said retention detent retains said microprotrusions inside said housing after said push button has been fully depressed.

4. The abrader device according to claim 3, wherein said abrader is removably mounted to said base.

5. The abrader device according to claim 1, wherein said abrader is permanently adhered to said base.

6. The abrader device according to claim 1, wherein said abrader is removably mounted to said base.

7. The abrader device according to claim 1, wherein said device further comprises a retraction spring disposed between said housing and said base, wherein said retraction spring retracts the abrader into the device.

8. The abrader device according to claim 1, wherein said device further comprises a first end of said housing which is adapted to stretch the skin when the device is pressed against the skin, thereby providing a tight skin area to aid the abrading surface in scraping the skin area.

9. The abrader device according to claim 7, wherein said housing has a first end adapted to stretch the skin when the device is pressed against the skin, thereby providing a tight skin area to aid the abrader surface in scraping the skin area.