Device, systems and methods for localized heating of a vessel and/or in combination with MR/NMR imaging of the vessel and surrounding tissue

• US 7,422,568 B2
• Filed: 04/01/2003
• Issued: 09/09/2008
• Est. Priority Date: 04/01/2002
• Status: Expired due to Fees

• Current Assignee: Johns Hopkins University
• Original Assignee: Johns Hopkins University
• Inventors: Atalar, Ergin, Yang, Xiaoming, Yeung, Christopher
• Primary Examiner(s): Gibson; Roy D.
• Assistant Examiner(s): ROANE, AARON F
• Application Number:
  US10/404,903
• Publication Number:
  US 20040024434A1
• Time in Patent Office: 1,988 Days
• Field of Search: 604/93.01, 604/96.01, 604/507, 604 19- 22, 604/48, 604/95.01, 606/213, 606191-194, 606/198
• US Class Current: 604/93.01
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 2018/00404 Blood vessels other than those in or around the heart
• CPC Class Codes: A61B 2018/144 Wire
• CPC Class Codes: A61B 2090/374 NMR or MRI
• CPC Class Codes: A61B 2218/002 Irrigation

Abstract

Featured are devices, systems and methods for localized heating of a vessel as well as devices, systems and methods for MR/NMR imaging of a vessel while locally heating a portion of the vessel. More particularly featured are such devices, systems and methods for use when administering or delivering therapeutic agents including genes and/or drugs to the tissues of the vessel. Such a method includes positioning a thermal energy delivery device proximal a target site with the vessel of a body and activating the thermal energy delivery device so as to heat the target site thereby locally increasing a temperature of tissue at the target site. In further embodiments, the method includes introducing a therapeutic medium to the target site over a predetermined time period, and wherein said activating occurs at least one of before, during or after said step of introducing.

Claims

1. A method for delivering a therapeutic medium to a target site of a vessel, said method comprising the steps of:

positioning a thermal energy delivery and imaging device proximal to the target site;

introducing the therapeutic medium to the target site over a predetermined time period;

activating the thermal energy delivery and imaging device so as to heat the internal target site thereby locally increasing a temperature of tissue at the target site; and

imaging the body using an MR/NMR imaging technique during said steps of introducing and activating the therapeutic medium;

wherein said activating occurs before and during said step of introducing, and wherein the therapeutic medium includes a gene therapy agent.

2. The method of claim 1, wherein said steps of positioning includes:

introducing a catheter that houses the thermal energy delivery device into one of a lumen or body cavity of a body; and

manipulating the catheter so as to traverse the body lumen or body cavity and be positioned proximal the target site.

3. The method of claim 2, wherein the catheter includes a balloon member and wherein said step of positioning further includes the step of inflating the balloon member so as to at least locally position the thermal energy delivery device at desired position with respect to the target site.

4. The method of claim 3, wherein the target site is a vessel lumen and wherein said inflating includes inflating the balloon member so as to local position the thermal energy device so as to be generally located positioned a center of the vessel lumen.

5. The method of claim 1, wherein the target site includes a wall of a blood vessel of the body.

6. A method for delivering a therapeutic medium to a target site of a vessel, said method comprising the steps of:

introducing a catheter that houses a thermal energy delivery and imaging device into one of a lumen or body cavity of a body;

manipulating the catheter so as to traverse the body lumen or body cavity and so the thermal energy delivery and imaging device is positioned proximal the target site;

activating the thermal energy delivery and imaging device so as to heat the internal target site thereby locally increasing a temperature of tissue at the target site,

wherein said activating occurs;

before and during introducing the therapeutic medium,

introducing the therapeutic medium to the target site over a predetermined time period; and

imaging the body using an MR/NMR imaging technique during said steps of manipulating, activating the thermal energy delivery and imaging device and introducing the therapeutic medium.

7. The method of claim 6, wherein said steps of imaging and activating are conducted at essentially the same time.

8. A method for delivering a therapeutic medium to a target site of a vessel, said method comprising the steps of:

positioning a thermal energy delivery and imaging device proximal the target site;

activating the thermal energy delivery and imaging device so as to heat the internal target site thereby locally increasing a temperature of tissue at the target site;

wherein said activating occurs

before and during introducing the therapeutic medium,

introducing the therapeutic medium to the target site over a predetermined time period; and

imaging the body using an MR/NMR imaging technique during said steps of positioning, activating and introducing the therapeutic medium;

wherein the thermal energy delivery and imaging device is used to detect MR/NMR signals from the target site.

9. The method of claim 8, wherein said steps of positioning includes:

introducing a catheter that houses the thermal energy delivery and imaging device into one of a lumen or body cavity of a body; and

manipulating the catheter so as to traverse the body lumen or body cavity and so the thermal energy delivery and imaging device is positioned proximal the target site.

10. The method of claim 9, wherein the catheter includes a balloon member and said step of positioning further includes the step of inflating the balloon member so as to at least locally position the thermal energy delivery and imaging device at desired position with respect to the target site.

11. The method of claim 10, wherein the target site is a vessel lumen and wherein said inflating includes inflating the balloon member so as to local position the thermal energy and delivery device so as to be generally located positioned a center of the vessel lumen.

12. The method of claim 8, wherein the therapeutic medium further includes a contrast agent and wherein said imaging includes imaging the therapeutic medium including the contrast agent being introduced.

13. The method of claim 8, wherein the therapeutic medium includes a gene therapy agent.

14. The method of claim 8, wherein the target site includes a wall of a blood vessel of the body.

15. The method of claim 8, wherein a volume of tissue in which thermal energy is delivered during said step of activating is different than another volume of tissue being imaged during said step of imaging.

16. The method of claim 8, wherein fluid flows through the vessel and wherein the method further comprises the step of maintaining a flow of fluid through the vessel during said steps of positioning and activating.

17. The method of claim 16, further comprising the step of configuring the thermal energy delivery and imaging device so as to establish one or more flow paths that fluidly couple an upstream portion of the vessel that is upstream of the thermal energy delivery to a downstream portion of the vessel.

18. The method of claim 8, wherein the thermal energy delivery and imaging device includes a wire to generate the heat energy and to detecting MR/NMR signals and the method further comprises filtering signal outputs from the wire so as to exclude signals that are not in the frequency band(s) for the MR/NMR signals from being used for imaging.

19. The method of claim 8, wherein said steps of imaging and activating are conducted at essentially the same time.

20. A method for delivering a therapeutic medium to a target site of a vessel in which fluid flows, said method comprising the steps of:

positioning a thermal energy delivery and imaging device proximal the target site;

activating the thermal energy delivery and imaging device so as to heat the internal target site thereby locally increasing a temperature of tissue at the target site;

wherein said activating occurs

before and during introducing the therapeutic medium,

maintaining a flow of fluid through the vessel during said steps of activating and introducing the therapeutic medium; and

imaging the body using an MR/NMR imaging technique during said steps of positioning, activating the thermal energy delivery and imaging device and introducing the therapeutic medium;

wherein the thermal energy delivery and imaging device is used to detect MR/NMR signals from the target site.

21. The method of claim 20, further comprising the step of configuring the thermal energy delivery and imaging device so as to establish one or more flow paths that fluidly couple an upstream portion of the vessel that is upstream of the thermal energy delivery to a downstream portion of the vessel.

22. The method of claim 20, wherein said steps of positioning includes:

introducing a catheter that houses the thermal energy delivery and imaging device into one of a lumen or body cavity of a body; and

manipulating the catheter so as to traverse the body lumen or body cavity and so the thermal energy delivery and imaging device is positioned proximal the target site.

23. The method of claim 20, wherein the therapeutic medium includes a gene therapy agent.

24. The method of claim 22, wherein the catheter includes a balloon member and said step of positioning further includes the step of inflating the balloon member so as to at least locally position the thermal energy delivery and imaging device at desired position with respect to the target site.

25. The method of claim 24, wherein the target site is a vessel lumen and wherein said inflating includes inflating the balloon member so as to local position the thermal energy delivery and imaging device so as to be generally located positioned a center of the vessel lumen.

26. The method of claim 20, wherein the target site includes a wall of a blood vessel of the body.

27. The method of claim 20, further comprising the step of imaging the target site using an MR/NMR imaging technique at least during said step of activating the heat source and introducing the therapeutic medium.

28. The method of claim 27, wherein said imaging is conducted during said step of positioning.

29. The method of claim 27, wherein the therapeutic medium further includes a contrast agent and wherein said imaging includes imaging the therapeutic medium including the contrast agent being introduced.

30. The method of claim 27, wherein a volume of tissue in which thermal energy is delivered during said step of activating is different than another volume of tissue being imaged during said step of imaging.

31. The method of claim 27, further comprising the step of configuring the thermal energy delivery device so as to include an antenna for detecting MR/NMR signals and wherein said step of imaging is conducted during said steps of positioning, activating and introducing.

32. The method of claim 31, wherein the thermal energy delivery and imaging device includes a wire to generate the heat energy and to act as the antenna, and the method further comprises filtering signal outputs from the wire so as to exclude signals that are not in the frequency band(s) for the MR/NMR signals from being used for imaging.

33. The method of claim 27, wherein said steps of imaging and activating are conducted at essentially the same time.