Multi-analyte reference solutions
First Claim
1. A reference solution for use in instruments that analyze biological samples, comprising 7-15% of a water soluble polymer by weight, 6-10% of a glycol by weight, and 5-10% of a polysaccharide by weight, wherein the reference solution has a conductivity corresponding to a known hematocrit level of a blood sample.
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Abstract
The present invention provides a reference solution for use in instruments that determine hematocrit levels in biological samples by measuring the resistance and/or conductivity of the biological samples. A reference solution according to the invention achieves conductivities representative of known hematocrit levels in blood, while maintaining tolerable levels of interference with the measurement of other analytes in the reference solution.
97 Citations
30 Claims
- 1. A reference solution for use in instruments that analyze biological samples, comprising 7-15% of a water soluble polymer by weight, 6-10% of a glycol by weight, and 5-10% of a polysaccharide by weight, wherein the reference solution has a conductivity corresponding to a known hematocrit level of a blood sample.
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25. A reference solution for use in instruments that analyze biological samples, comprising:
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7-15% polyethylene glycol by weight, 6-10% ethylene glycol by weight, and 5-10% dextran by weight, wherein the reference solution has a conductivity corresponding to a known hematocrit level of a blood sample. - View Dependent Claims (26, 27)
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28. A reference solution for use in instruments that analyze biological samples, comprising:
7-11% polyethylene glycol by weight and 5-9% dextran by weight, wherein the dextran has a molecular weight ranging from about 8,000 to about 40,000 and wherein the reference solution has a conductivity corresponding to a known hematocrit level of a blood sample.
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29. A method of calibrating an instrument that analyzes biological samples, comprising:
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(a) introducing a reference solution to the instrument, the reference solution comprising a water soluble polymer, a glycol, and a polysaccharide, wherein the reference solution has a conductivity corresponding to a known hematocrit level of a blood sample; (b) obtaining a signal from the instrument corresponding to a conductivity of the reference solution; and (c) adjusting the instrument so that the signal obtained from the instrument is representative of the conductivity corresponding to the known hematocrit level. - View Dependent Claims (30)
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Specification