Method for treating severe heart failure and medicament therefor
First Claim
1. A method for treating severe heart failure of New York Heart Association Class IV, comprising administering to a patient in need thereof a therapeutically effective amount of an active compound, 5-hydroxy-7-chloro-1-[2-methyl-4-(2-methyl benzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepine or a pharmaceutically acceptable salt thereof in a daily dose of less than 0.6 mg/kg.
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Accused Products
Abstract
A method for treating severe heart failure, comprising administering to a patient an effective amount of a benzazepine compound (1): wherein R1 is H or halogen, R2 is OH, or —NR5R6 (R5 and R6 are H or lower alkyl, R3 is H, halogen, lower alkyl, or lower alkoxy, R4 is halogen, lower alkyl or lower alkoxy, or a salt thereof, and a pharmaceutical composition containing the benzazepine compound (1) or a salt thereof and use of the compound (1) or a salt thereof for preparing a medicament for treatment of severe heart failure
24 Citations
4 Claims
- 1. A method for treating severe heart failure of New York Heart Association Class IV, comprising administering to a patient in need thereof a therapeutically effective amount of an active compound, 5-hydroxy-7-chloro-1-[2-methyl-4-(2-methyl benzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepine or a pharmaceutically acceptable salt thereof in a daily dose of less than 0.6 mg/kg.
- 3. A method for treating severe heart failure of New York Heart Association Class IV, comprising administering to a patient in need thereof a therapeutically effective amount of an active compound, 5-hydroxy-7-chloro-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepine or a pharmaceutically acceptable salt thereof in a daily dose of 15 to 45 mg.
Specification