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Oligonucleotides and analogs labeled with energy transfer dyes

  • US 7,423,140 B2
  • Filed: 12/28/2006
  • Issued: 09/09/2008
  • Est. Priority Date: 05/03/1996
  • Status: Expired due to Fees
First Claim
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1. A fluorescently-labeled reagent comprising an oligonucleotide or an oligonucleotide analog and an energy transfer dye, wherein energy transfer dye is covalently linked to the oligonucleotide or oligonucleotide analog, and comprises:

  • a fluorescein donor dye capable of absorbing light at a first wavelength and emitting excitation energy in response thereto;

    a 4,7-dichlororhodamine acceptor dye capable of absorbing the excitation energy emitted by the donor dye and fluorescing at a second wavelength in response thereto; and

    a non-nucleosidic linker linking the 5- or 6-position of the fluorescein donor dye to the 5- or 6-position of the 4,7-dichlororhodamine acceptor dye.

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