Method and apparatus for automatic location of blood flow with Doppler ultrasound

• US 7,425,198 B2
• Filed: 10/21/2003
• Issued: 09/16/2008
• Est. Priority Date: 02/09/2000
• Status: Expired due to Term

• Current Assignee: Spentech Incorporated
• Original Assignee: Spentech Incorporated
• Inventors: Voie, Arne H., Spencer, Merrill P., Moehring, Mark A.
• Primary Examiner(s): Jaworski; Francis J.
• Application Number:
  US10/691,122
• Publication Number:
  US 20040138563A1
• Time in Patent Office: 1,792 Days
• Field of Search: 600/439, 600440-443, 600/447, 600453-457, 600/587, 128/916, 601/2, 604/22
• US Class Current: 600/454
• CPC Class Codes: A61B 17/22004 using mechanical vibrations, e.g. ultrasonic shock waves A61B17/225 takes precedence
• CPC Class Codes: A61B 17/2256 with means for locating or checking the concrement, e.g. X-ray apparatus, imaging means A61B17/2255 takes precedence
• CPC Class Codes: A61B 2090/378 using ultrasound
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/0808 for diagnosis of the brain
• CPC Class Codes: A61B 8/0816 using echo-encephalography
• CPC Class Codes: A61B 8/0833 involving detecting or locating foreign bodies or organic structures
• CPC Class Codes: A61B 8/463 characterised by displaying multiple images or images and diagnostic data on one display composite display in devices for short-range imaging with acoustic waves G01S7/52074
• CPC Class Codes: A61B 8/481 involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream analysis of echo signal exploiting properties of a contrast enhancer in devices for short-range imaging with acoustic waves G01S7/52039
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092

Abstract

A method and apparatus for combining therapeutic pulsed or continuous-wave ultrasound with diagnostic pulsed ultrasound are described. In both a therapeutic mode and in a diagnostic mode, the ultrasound is administered from a single probe to a patient suffering from thrombosis. The ultrasound can have the same or different frequency ranges in the diagnostic and therapeutic modes. The pulsed or continuous-wave ultrasound in the therapeutic mode enhances a lysing effect of a thrombolytic agent. The pulsed ultrasound in the diagnostic mode allows monitoring of blood flow to locate a thrombus, to determine an optimal window to administer the therapeutic pulsed ultrasound, and to detect when recanalization has occurred. If an operator attends the device, a graphical display operates during the diagnostic mode to display an image representative of the blood flow.

Claims

1. A Doppler ultrasound system for monitoring blood flow, comprising:

an ultrasound transducer having a plurality of ultrasound transducer elements;

an ultrasound pulser circuit operatively coupled to the ultrasound transducer and configured to generate signals to drive a set of elements of the plurality of ultrasound transducer elements to radiate an ultrasound beam;

an ultrasound receiving circuit operatively coupled to the ultrasound transducer and configured to process signals detected from reflections of the ultrasound beam by at least a portion of the plurality of ultrasound transducer elements and generate processed data therefrom representative of reflected signal power of blood flow; and

a computer operatively coupled to the ultrasound pulser circuit and the ultrasound receiving circuit, the computer configured to control the ultrasound pulser circuit to drive different sets of elements of the ultrasound transducer, control the ultrasound receiving circuit to generate processed data for the different sets of elements, and further configured to analyze the processed data for the different sets of elements to determine a window through which blood flow is detected, the window generally defined by a selected one of the sets of elements for which processed data is provided by the ultrasound receiving circuit and operating conditions for the pulser and receiving circuits for the selected set of elements.

2. The Doppler ultrasound system of claim 1 wherein the ultrasound transducer comprises an ultrasound transducer having an array of triangular shaped ultrasound transducer elements.

3. The Doppler ultrasound system of claim 2 wherein the ultrasound pulser circuit comprises an ultrasound pulser circuit configured to generate signals to drive groups of six triangular shaped ultrasound transducer elements arranged in a hexagonal shape to radiate an ultrasound beam, and the ultrasound receiving circuit comprises an ultrasound receiving circuit configured to process signals detected from reflections of the ultrasound beam radiated by any of the groups of ultrasound transducer elements and generate the processed data therefrom.

4. The Doppler ultrasound system of claim 1 wherein the ultrasound transducer comprises an ultrasound transducer having an array of quadrilateral shaped ultrasound transducer elements.

5. The Doppler ultrasound system of claim 4 wherein the ultrasound pulser circuit comprises an ultrasound pulser circuit configured to generate signals to drive groups of four adjacent quadrilateral shaped ultrasound transducer elements to radiate an ultrasound beam, and the ultrasound receiving circuit comprises an ultrasound receiving circuit configured to process signals detected from reflections of the ultrasound beam radiated by any of the groups of ultrasound transducer elements and generate the processed data therefrom.

6. The Doppler ultrasound system of claim 1 wherein the computer comprises a computer configured to control the ultrasound pulser circuit to generate the signals driving the set of elements of the plurality of ultrasound transducers to radiate and steer the ultrasound beam by electronically controlling the elements of the set of ultrasound transducer elements, the computer further configured to control the ultrasound receiving circuit to process signals detected from reflections of the ultrasound beam radiated from the electronically controlled elements.

7. The Doppler ultrasound system of claim 6 wherein the computer is configured to control the ultrasound pulser circuit to generate the signals driving the set of elements of the plurality of ultrasound transducers to radiate and steer the ultrasound beam by electronically phasing the elements and is further configured to control the ultrasound receiving circuit to process signals detected from reflections of the ultrasound beam radiated from the electronically phased elements.

8. The Doppler ultrasound system of claim 1 wherein the computer comprises a computer configured to execute a pattern recognition algorithm that determines from the processed data the window through which blood flow is detected.

9. A Doppler ultrasound system for monitoring blood flow, comprising:

an ultrasound transducer having a plurality of ultrasound transducer elements;

an ultrasound pulser circuit operatively coupled to the ultrasound transducer and configured to generate signals to drive a set of elements of the plurality of ultrasound transducer elements to radiate an ultrasound beam;

an ultrasound receiving circuit operatively coupled to the ultrasound transducer and configured to process signals detected from reflections of the ultrasound beam by at least a portion of the plurality of ultrasound transducer elements and generate processed data therefrom representative of detected blood flow including reflected signal power of the detected blood flow; and

a computer operatively coupled to the ultrasound pulser circuit and the ultrasound receiving circuit, the computer configured to control the ultrasound pulser circuit to drive different sets of elements of the ultrasound transducer, control the ultrasound receiving circuit to generate processed data for the different sets of elements, and further configured to analyze the processed data for the different sets of elements to select one set of elements from which the ultrasound beam is radiated and blood flow is detected.

10. The Doppler ultrasound system of claim 9 wherein the ultrasound transducer comprises an ultrasound transducer having an array of triangular shaped ultrasound transducer elements.

11. The Doppler ultrasound system of claim 10 wherein the ultrasound pulser circuit comprises an ultrasound pulser circuit configured to generate signals to drive groups of six triangular shaped ultrasound transducer elements arranged in a hexagonal shape to radiate an ultrasound beam, and the ultrasound receiving circuit comprises an ultrasound receiving circuit configured to process signals detected from reflections of the ultrasound beam radiated by any of the groups of ultrasound transducer elements and generate the processed data therefrom.

12. The Doppler ultrasound system of claim 9 wherein the ultrasound transducer comprises an ultrasound transducer having an array of quadrilateral shaped ultrasound transducer elements.

13. The Doppler ultrasound system of claim 12 wherein the ultrasound pulser circuit comprises an ultrasound pulser circuit configured to generate signals to drive groups of four adjacent quadrilateral shaped ultrasound transducer elements to radiate an ultrasound beam, and the ultrasound receiving circuit comprises an ultrasound receiving circuit configured to process signals detected from reflections of the ultrasound beam radiated by any of the groups of ultrasound transducer elements and generate the processed data therefrom.

14. The Doppler ultrasound system of claim 9 wherein the computer comprises a computer configured to control the ultrasound pulser circuit to generate the signals driving the set of elements of the plurality of ultrasound transducers to radiate and steer the ultrasound beam by electronically controlling the elements of the set of ultrasound transducer elements, the computer further configured to control the ultrasound receiving circuit to process signals detected from reflections of the ultrasound beam radiated from the electronically controlled elements.

15. The Doppler ultrasound system of claim 14 wherein the computer is configured to control the ultrasound pulser circuit to generate the signals driving the set of elements of the plurality of ultrasound transducers to radiate and steer the ultrasound beam by electronically phasing the signals driving the elements and is further configured to control the ultrasound receiving circuit to process signals detected from reflections of the ultrasound beam radiated from the electronically phased elements by phasing the detected signals.

16. The Doppler ultrasound system of claim 9 wherein the computer comprises a computer configured to execute a pattern recognition algorithm that determines from the processed data which set of elements from which the ultrasound beam is radiated and blood flow is detected.

17. A Doppler ultrasound system, comprising:

an ultrasound transducer having an array of ultrasound transducer elements;

an ultrasound pulser circuit coupled to the ultrasound transducer to drive a selected plurality of the ultrasound transducer elements to deliver an ultrasound beam;

a processing circuit coupled to the ultrasound transducer to process signals detected from reflections of the ultrasound beam by the selected plurality of ultrasound transducer elements and generate Doppler shift data in response thereto representative of blood flow information; and

a computer coupled to the processing circuit to execute a software algorithm that analyzes the Doppler shift data and determines which of the selected plurality of ultrasound transducer elements of the array provide an optimum location from which to deliver ultrasound and detect the signals from reflections of the ultrasound beam to acquire blood flow information based on signal power of reflected ultrasound.

18. The Doppler ultrasound system of claim 17 wherein the ultrasound transducer comprises an ultrasound transducer having an array of triangular shaped ultrasound transducer elements.

19. The Doppler ultrasound system of claim 18 wherein the ultrasound pulser circuit comprises an ultrasound pulser circuit configured to generate signals to drive groups of six triangular shaped ultrasound transducer elements arranged in a hexagonal shape to deliver the ultrasound beam, and the processing circuit comprises a processing circuit configured to process signals detected from reflections of the ultrasound beam delivered by any of the groups of ultrasound transducer elements and generate the Doppler shift data representative of the blood flow information in response thereto.

20. The Doppler ultrasound system of claim 17 wherein the ultrasound transducer comprises an ultrasound transducer having an array of quadrilateral shaped ultrasound transducer elements.

21. The Doppler ultrasound system of claim 20 wherein the ultrasound pulser circuit comprises an ultrasound pulser circuit configured to generate signals to drive groups of four adjacent quadrilateral shaped ultrasound transducer elements to deliver the ultrasound beam, and the processing circuit comprises a processing circuit configured to process signals detected from reflections of the ultrasound beam delivered by any of the groups of ultrasound transducer elements and generate the Doppler shift data representative of the blood flow information in response thereto.

22. The Doppler ultrasound system of claim 17 wherein the computer comprises a computer further configured to control the ultrasound pulser circuit to generate the signals driving the set of elements of the plurality of ultrasound transducers to radiate and steer the ultrasound beam by electronically controlling the elements of the set of ultrasound transducer elements, the computer further configured to control the processing circuit to process signals detected from the reflections of the ultrasound beam radiated from the electronically controlled elements.

23. The Doppler ultrasound system of claim 22 wherein the computer is configured to control the ultrasound pulser circuit to generate the signals driving the set of elements of the plurality of ultrasound transducers to radiate and steer the ultrasound beam by electronically phasing the signals driving the elements and is further configured to control the ultrasound receiving circuit to process signals detected from reflections of the ultrasound beam radiated from the electronically phased elements by phasing the detected signals.

24. The Doppler ultrasound system of claim 22 wherein the processing circuit is further configured to process the signals detected from the reflections of the ultrasound beam radiated from the electronically controlled elements and generate Doppler shift data for a plurality of control conditions representative of blood flow information, and the computer is further configured to analyze the Doppler shift data for the plurality of control conditions to determine an optimum control condition to acquire blood flow information.

25. The Doppler ultrasound system of claim 17 wherein the computer comprises a computer configured to execute a pattern recognition algorithm that determines from the Doppler shift data which selected plurality of ultrasound transducer elements provide an optimum condition.

26. In a Doppler ultrasound system, a method of detecting blood flow, comprising:

providing an ultrasound transducer having a plurality of ultrasound transducer elements;

delivering ultrasound from groups of ultrasound transducer elements, each group defining a transmitting group;

analyzing signals detected from reflections of the ultrasound beam at groups of ultrasound transducer elements to determine reflected signal power for each of the groups, each group defining a receiving group; and

determining from the reflected signal power for each of the transmitting and receiving groups a selected transmitting group and a selected receiving group of ultrasound transducer elements representing an optimum set of ultrasound transducer elements for monitoring blood flow.

27. The method of claim 26 wherein a receiving group of ultrasound transducer elements at which reflected ultrasound signals are detected is the same as the transmitting group of ultrasound transducer elements from which the ultrasound is delivered.

28. The method of claim 26 wherein providing the ultrasound transducer comprises providing an ultrasound transducer having an array of triangular shaped ultrasound transducer elements.

29. The method of claim 28 wherein delivering ultrasound from transmitting groups of ultrasound transducers comprises delivering ultrasound from groups of six triangular shaped ultrasound transducer elements arranged in a hexagonal shape.

30. The method of claim 26 wherein providing the ultrasound transducer comprises providing an ultrasound transducer having an array of quadrilateral shaped ultrasound transducer elements.

31. The method of claim 30 wherein delivering ultrasound from transmitting groups of ultrasound transducers comprises delivering ultrasound from groups of four adjacent quadrilateral shaped ultrasound transducer elements.

32. The method of claim 26, further comprising

electronically controlling the ultrasound transducer elements of a transmitting group to steer the ultrasound beam delivered by the transmitting group of ultrasound transducer elements;

processing signals detected from the reflections of the ultrasound beam radiated from the electronically controlled elements detected by a receiving group to generate processed data representative of detected blood flow and reflected signal power of the detected blood flow for a plurality of control conditions; and

analyzing the processed data for the plurality of control conditions to determine an optimum control condition for detecting blood flow.

33. The method of claim 32 wherein electronically controlling the ultrasound transducer of a transmitting group to steer the ultrasound beam comprises electronically phasing the signals driving the transducer elements of a transmitting group and wherein processing signals detected from the reflections of the ultrasound beam radiated from the electronically controlled elements comprises processing signals detected from reflections of the ultrasound beam radiated from the electronically phased elements by phasing the detected signals.

34. The method of claim 26, further comprising executing a pattern recognition algorithm to determine from the blood flow information the optimum location for detecting blood flow.

35. In a Doppler ultrasound system, a method of determining an optimum window through which blood flow is detected, the method comprising:

selecting a region on a body surface of the patient;

placing on the body surface a single ultrasound probe having a plurality of transducer elements arranged in an array, the array defining a plurality of areas within the region;

administering ultrasound from the ultrasound probe to a first one of the areas;

evaluating signal power of reflected ultrasound through a window for the first area;

if the window for the first area is not an optimum window, administering the ultrasound to a second one of the areas, at least a portion of the second area including at least a portion of the first area;

evaluating signal power of reflected ultrasound through a window for the second area; and

repeating the administration of the ultrasound to another area if prior areas administered with ultrasound do not substantially include the optimum window, until an area having substantially the optimum window is located.

36. The method of claim 35, further comprising

electronically controlling the ultrasound transducer elements of a transmitting group to steer the ultrasound beam delivered by the transmitting group of ultrasound transducer elements;

processing signals detected from reflections of the ultrasound beam radiated from the electronically controlled elements detected by a receiving group to generate processed data representative of detected blood flow and reflected signal power of the detected blood flow for a plurality of control conditions; and

analyzing the processed data for the plurality of control conditions to determine an optimum control condition for detecting blood flow.

37. The method of claim 35 wherein electronically controlling the ultrasound transducer of a transmitting group to steer the ultrasound beam comprises electronically phasing the signals driving the transducer elements of the transmitting group and wherein processing signals detected from the reflections of the ultrasound beam radiated from the electronically controlled elements comprises processing signals detected from reflections of the ultrasound beam radiated from the electronically phased elements by phasing the detected signals.

38. The method of claim 35, further comprising executing a pattern recognition algorithm to determine from the blood flow information the optimum location for detecting blood flow.