Method and apparatus for ultrasonic continuous, non-invasive blood pressure monitoring

• US 7,425,199 B2
• Filed: 09/23/2004
• Issued: 09/16/2008
• Est. Priority Date: 12/30/2003
• Status: Active Grant

• Current Assignee: General Electric Company
• Original Assignee: General Electric Company
• Inventors: Thomenius, Kai Erik, Hoctor, Ralph Thomas, Dentinger, Aaron Mark
• Primary Examiner(s): Nasser, Jr.; Robert L.
• Assistant Examiner(s): MALLARI, PATRICIA C
• Application Number:
  US10/948,434
• Publication Number:
  US 20050143640A1
• Time in Patent Office: 1,454 Days
• Field of Search: 600/438, 600/453
• US Class Current: 600/485
• CPC Class Codes: A61B 8/04 Measuring blood pressure
• CPC Class Codes: A61B 8/4236 characterised by adhesive patches

Abstract

Ultrasound is used to provide input data for a blood pressure estimation scheme. The use of transcutaneous ultrasound provides arterial lumen area and pulse wave velocity information. In addition, ultrasound measurements are taken in such a way that all the data describes a single, uniform arterial segment. Therefore a computed area relates only to the arterial blood volume present. Also, the measured pulse wave velocity is directly related to the mechanical properties of the segment of elastic tube (artery) for which the blood volume is being measured. In a patient monitoring application, the operator of the ultrasound device is eliminated through the use of software that automatically locates the artery in the ultrasound data, e.g., using known edge detection techniques. Autonomous operation of the ultrasound system allows it to report blood pressure and blood flow traces to the clinical users without those users having to interpret an ultrasound image or operate an ultrasound imaging device.

Claims

1. A method for monitoring of pressure in an arterial lumen, comprising the following steps:

(a) converting acquired disturbance propagating waveform information corresponding to energy transmitted and returned from a lumen wall, flow through the lumen and adjacent areas surrounding the lumen, into electrical signals;

(b) forming at least one spatial covariance matrix of frequency components of the propagating waveform measured at a plurality of locations along the lumen;

(c) processing the at least one spatial covariance matrix to estimate a velocity of a pulse wave and any reflections traveling through the lumen; and

,

(d) computing the pressure as a function of the estimated velocity.

2. The method as recited in claim 1, wherein the disturbance propagating waveform information is acquired using at least one of an ultrasonic imaging system, a magnetic resonance imaging (MRI) system, a computed tomography (CT) system, and a fluoroscopic X-ray imaging system.

3. The method as recited in claim 1 wherein the lumen is an artery and the computed pressure corresponds to blood pressure through the lumen.

4. The method as recited in claim 3, wherein the computed pressure further corresponds to an indicator of elasticity of the lumen.

5. The method as recited in claim 4, wherein the blood pressure and elasticity are used in the diagnosis in at least one of arterial physiological state or disease.

6. The method as recited in claim 1, wherein step (b) further comprises the following steps:

estimating a time-varying arterial wall velocity with which respective anterior and a posterior walls of the lumen are moving in relation to one another;

subjecting the time-varying velocity estimates to Fourier transformation;

forming vectors of Fourier transformation coefficient indices; and

,

estimating a respective value of the pulse wave velocity that minimizes an observation error for each of a range of Fourier transformation coefficient indices.

7. The method as recited in claim 6, further comprising:

combining said estimated values of the pulse wave velocity using a trimmed mean algorithm.

8. The method as recited in claim 6 wherein the arterial wall velocity is a measure of at least one of arterial wall velocity or arterial wall diameter.

9. A system for autonomous monitoring of pressure in an arterial lumen, comprising an image acquisition system, data processing means, and means for delivering signals derived from the output of the image acquisition system to said data processing means, wherein said data processing means are programmed to perform the following steps:

(a) converting acquired disturbance propagating waveform information corresponding to energy transmitted and returned from a lumen wall, flow through the lumen and adjacent areas surrounding the lumen, into electrical signals;

(b) forming at least one spatial covariance matrix of frequency components of the propagating waveform measured at a plurality of locations along the lumen;

(c) processing the at least one spatical covariance matrix to estimate a velocity of a pulse wave and any reflections traveling through the lumen; and

,

(d) computing the pressure as a function of the estimated velocity.

10. The system as recited in claim 9, wherein the image acquisition system comprises at least one of an ultrasonic imaging system, a magnetic resonance imaging (MRI) system, a computed tomography (CT) system, and a fluoroscopic X-ray imaging system.

11. The system as recited in claim 9 wherein the lumen is an artery and the pressure corresponds to blood pressure through the lumen.

12. The system as recited in claim 11 wherein the pressure further corresponds to an indicator of elasticity of the lumen.

13. The system as recited in claim 12, wherein the data processing means uses the blood pressure and elasticity in the diagnosis in at least one of arterial health or disease.

14. The system as recited in claim 9, wherein the data processing step (b) further comprises the following steps:

estimating a time-varying arterial wall velocity with which respective anterior and a posterior walls of the lumen are moving in relation to one another;

subjecting the time-varying velocity estimates to Fourier transformation;

forming vectors Fourier transformation coefficient indices; and

,

estimating a respective value of the pulse wave velocity that minimizes an observation error for each of a range of Fourier transformation coefficient indices.

15. The system as recited in claim 14 further comprising:

combining said estimated values of the pulse wave velocity using a trimmed mean algorithm.

16. The system as recited in claim 14 wherein the arterial wall velocity is a measure of at least one of arterial wall velocity or arterial wall diameter.