Needleless injector

• US 7,425,204 B2
• Filed: 04/28/2005
• Issued: 09/16/2008
• Est. Priority Date: 10/26/2001
• Status: Expired due to Fees

• Current Assignee: Massachusetts Institute of Technology
• Original Assignee: Massachusetts Institute of Technology
• Inventors: Hunter, Ian W., Angel, Aimee B.
• Primary Examiner(s): Lucchesi; Nicholas D.
• Assistant Examiner(s): BERDICHEVSKY, AARTI
• Application Number:
  US11/117,082
• Publication Number:
  US 20050256448A1
• Time in Patent Office: 1,237 Days
• Field of Search: 604/68, 604/48, 604/69, 604/70, 604/71, 604/72, 604/73, 604/131, 604/134, 604/181, 604/187, 605/27, 605/28
• US Class Current: 604/68
• CPC Class Codes: A61M 2205/0266 Shape memory materials
• CPC Class Codes: A61M 2205/0272 Electro-active or magneto-active materials
• CPC Class Codes: A61M 5/30 Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
• CPC Class Codes: A61M 5/31511 Piston or piston-rod constructions, e.g. connection of piston with piston-rod A61M5/5066 takes precedence
• CPC Class Codes: F03G 7/065 using a shape memory element

Abstract

An injector includes a housing having a chamber for holding a liquid formulation of an active principle to be injected into a biological body and an output port in fluid communication with the chamber through which the liquid formulation is injected. A piston is positioned within the housing, and includes an end portion with substantially the same shape as the chamber. A magnetic force draws the piston and housing together to expel the liquid formulation out of the chamber through the output port.

Claims

1. An injector for injecting a substance into a biological body, comprising:

a chamber adapted to hold the substance to be injected and an output port in fluid communication with the chamber;

a drive element;

a magnetic force able to cause movement of the drive element; and

an actuator that opposes movement of the drive element and then allows the magnetic force to cause the drive element to move and thereby cause the expulsion of the substance out of the chamber through the output port.

2. The injector of claim 1, wherein the actuator comprises shape memory alloy.

3. The injector of claim 1, wherein the actuator moves the drive element away from the output port when a potential is applied to the actuator, and allows the drive element to move towards the output port when the voltage is removed.

4. The injector of claim 2, wherein the actuator is one or more fibers of the shape memory alloy.

5. The injector of claim 2, further comprising a capacitor, wherein the potential is applied to the actuator when the capacitor discharges.

6. The injector of claim 1, wherein the injector has an injection pressure in the range of about 1 MPa to 300 MPa.

7. The injector of claim 1, wherein the injector has an injection pressure of at least 1 Mpa.

8. The injector of claim 1, wherein the substance is a drug.

9. The injector of claim 1, wherein the actuator comprises a contracting material, the actuator moving the drive element away from the output port when a potential is applied to the actuator, and the drive element moving towards the output port when the voltage is removed.

10. The injector of claim 1, wherein the actuator is attached to the drive element.

11. The injector of claim 1, wherein the expelled substance penetrates the skin without a needle.

12. The injector of claim 1, wherein the magnetic force is supplied by a permanent magnet.

13. An injector for injecting a substance into a biological body, comprising:

a chamber adapted to hold the substance to be injected and an output port in fluid communication with the chamber;

a drive element; and

a permanent magnet providing a magnetic force sufficient to result in a movement of the drive element to expel the substance from the chamber.

14. The injector of claim 13, wherein the drive element is a piston.

15. The injector of claim 14, wherein the force moves the piston and the output port together to expel the substance to penetrate the skin without a needle.

16. The injector of claim 15, further comprising an actuator that provides a counter force in opposition to the magnetic force of the permanent magnet to prevent the piston and output port from being drawn together and that reduces the counter force to allow the magnetic force to drive the piston and the output port together.

17. An injector as in claim 13, further comprising an actuator that moves the drive element against the magnetic force.