Processing set and methods for processing and treating a biological fluid

• US 7,425,304 B2
• Filed: 02/13/2006
• Issued: 09/16/2008
• Est. Priority Date: 06/03/1999
• Status: Expired due to Fees

• Current Assignee: Cerus Corporation, Fenwal Incorporated (Fresenius SE & Co. KGaA)
• Original Assignee: Cerus Corporation, Fenwal Incorporated (Fresenius SE & Co. KGaA)
• Inventors: Hei, Derek J., Mohiuddin, Mahmood, Metzel, Peyton S., de Gheldere, Serge, Clarke, Michael S., Cimino, George D.
• Primary Examiner(s): Warden; Jill
• Assistant Examiner(s): Nagpaul; Jyoti
• Application Number:
  US11/353,397
• Publication Number:
  US 20060197031A1
• Time in Patent Office: 946 Days
• Field of Search: 422 99-102, 422 63- 65, 604 4- 6, 210/94, 210/202, 210/335
• US Class Current: 422/63
• CPC Class Codes: A61J 1/10 Bag-type containers
• CPC Class Codes: A61L 2/0023 Heat
• CPC Class Codes: A61L 2/0035 Gamma radiation
• CPC Class Codes: A61L 2/0047 Ultraviolet radiation
• CPC Class Codes: A61L 2/007 Particle radiation, e.g. electron-beam, alpha or beta radiation
• CPC Class Codes: A61L 2/0082 using chemical substances
• CPC Class Codes: A61L 2/24 Apparatus using programmed or automatic operation
• CPC Class Codes: A61L 2/26 Accessories or devices or components used for biocidal treatment
• CPC Class Codes: A61L 2202/122 Chambers for sterilisation
• CPC Class Codes: A61L 2202/14 Means for controlling sterilisation processes, data processing, presentation and storage means, e.g. sensors, controllers, programs
• CPC Class Codes: A61L 2202/22 Blood or products thereof
• CPC Class Codes: A61M 1/0218 with filters
• CPC Class Codes: A61M 1/0236 with sampling means, e.g. sample bag or sampling port
• CPC Class Codes: A61M 1/0277 Frames constraining or supporting bags, e.g. during freezing
• CPC Class Codes: A61M 1/3681 by irradiation
• CPC Class Codes: A61M 1/3686 by removing photoactive agents after irradiation
• CPC Class Codes: B01D 15/00 Separating processes involving the treatment of liquids with solid sorbents using liquid sorbents B01D11/00; ion exchange processes or materials, sorbent materials in general B01J, e.g. sorbents for chromatography B01J20/281; for investigating or analysing materials G01N30/00; Apparatus therefor

Abstract

Apparatus, systems and methods are disclosed for treating a biological fluid with light. A container of biological fluid is introduced into a fluid treatment chamber where it is contacted with light provided by one or more light sources in proximity to the fluid treatment chamber. A drawer for holding containers of biological fluid introduces the containers into the chamber. Containers for holding the biological fluid are marked by the apparatus to indicate the status of the treatment.

Claims

1. A pre-assembled disposable fluid processing set for use in a photoactivation treatment of a biological fluid comprising:

a first container with a photochemical agent contained therein, said container being adapted for joinder to a source container of biological fluid and being enclosed within an overwrap that is impermeable to light of a selected photoactivating wavelength range;

a second container downstream of and pre-attached to said first container for holding the biological fluid and the photochemical agent during a photoactivation treatment, wherein said container is made of a material that is substantially translucent to light in the photoactivating wavelength range;

a sealed but openable flow path between said first and second containers;

a flow-through device downstream of and pre-attached to said second container for receiving at least said biological fluid from said second container, said device including adsorbent material for removing at least one or both of excess photochemical agent and photoactivation by-products from said biological fluid;

a sealed but openable flow path between said second container and said flow through device;

a container downstream of and pre-attached to said device for receiving said biological fluid from said device.

2. The disposable processing set of claim 1 comprising a tubing segment including an openable flow path for establishing flow communication between said device and said container downstream of said device.

3. The disposable fluid processing set of claim 1 wherein said overwrap is impermeable to light in the UVA wavelength range.

4. The disposable fluid processing set of claim 1 wherein said second container is made of a material that is substantially translucent to photoactivating light in the UVA range.

5. The disposable processing set of claim 1 further including a holder for temporarily holding at least said device.

6. The disposable processing set of claim 1 including a holder for temporarily holding said device and container downstream of said device.

7. The disposable fluid processing set of claim 1 wherein said openable flow paths include frangible connectors.

8. The disposable fluid processing set of claim 7 wherein said openable flow paths comprise plastic tubes with said frangible connectors disposed therein.