Cytokine zcytor17 ligand polypeptides
First Claim
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1. An isolated polypeptide comprising a sequence of amino acid residues having at least 95% sequence identity to:
- (a) amino acid residues 38 to 152 as shown in SEQ TD NO;
2;
(b) amino acid residues 27 to 164 as shown in SEQ ID NO;
2;
(c) amino acid residues 24 to 164 as shown in SEQ ID NO;
2; and
(d) amino acid residues 1 to 164 as shown in SEQ D NO;
2wherein the polypeptide induces proinflammatory cytokine production.
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Abstract
The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
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Citations
25 Claims
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1. An isolated polypeptide comprising a sequence of amino acid residues having at least 95% sequence identity to:
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(a) amino acid residues 38 to 152 as shown in SEQ TD NO;
2;(b) amino acid residues 27 to 164 as shown in SEQ ID NO;
2;(c) amino acid residues 24 to 164 as shown in SEQ ID NO;
2; and(d) amino acid residues 1 to 164 as shown in SEQ D NO;
2wherein the polypeptide induces proinflammatory cytokine production. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. An isolated polypeptide comprising a sequence of amino acid residues selected from:
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(a) amino acid residues 38 to 152 as shown in SEQ ID NO;
2; and(b) amino acid residues 24 to 164 as shown in SEQ ID NO;
2. - View Dependent Claims (18, 19, 20, 21)
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22. An isolated antigenic polypeptide comprising a sequence of at least 30 contiguous amino acid residues of SEQ ID NO:
- 2, wherein the antigenic polypeptide comprises the amino acid sequence selected from;
(a) amino acid residues 54 to 59 of SEQ ID NO;
2;(b) amino acid residues 129 to 134 of SEQ ID NO;
2;(c) amino acid residues 53 to 58 of SEQ ID NO;
2;(d) amino acid residues 35 to 40 of SEQ ID NO;
2;(e) amino acid residues 33 to 38 of SEQ ID NO;
2;(f) amino acid residues 114 to 119 of SEQ ID NO;
2;(g) amino acid residues 101 to 105 of SEQ ID NO;
2;(h) amino acid residues 126 to 131 of SEQ ID NO;
2;(i) amino acid residues 113 to 118 of SEQ ID NO;
2; and(j) amino acid residues 158 to 162 of SEQ ID NO;
2and wherein the polypeptide induces proinflammatory cytokine production. - View Dependent Claims (23)
- 2, wherein the antigenic polypeptide comprises the amino acid sequence selected from;
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24. An isolated protein produced by the method of culturing a cell comprising an expression vector comprising the following operably linked elements:
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(a) a transcription promoter; (b) a DNA segment comprising the sequence of nucleotides from nucleotide 139 to nucleotide 483 of SEQ ID NO;
1; and(c) a transcription terminator under conditions wherein the DNA segment is expressed; and
recovering the protein encoded by the DNA segment.
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25. An isolated polypeptide comprising at least 14 contiguous amino acid residues of SEQ ID NO:
- 2 wherein the polypeptide is used to produce an antibody.
Specification