FcγRIIB specific antibodies and methods of use thereof
First Claim
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1. A mouse monoclonal antibody produced by clone 2B6, having ATCC accession number PTA-4591 or an antigen binding fragment thereof.
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Abstract
The present invention relates to antibodies or fragments thereof that specifically bind FcγRIIB, particularly human FcγRIIB, with greater affinity than said antibodies or fragments thereof bind FcγRIIA, particularly human FcγRIIA. The invention provides methods of enhancing the therapeutic effect of therapeutic antibodies by administering the antibodies of the invention to enhance the effector function of the therapeutic antibodies. The invention also provides methods of enhancing efficacy of a vaccine composition by administering the antibodies of the invention.
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Citations
40 Claims
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1. A mouse monoclonal antibody produced by clone 2B6, having ATCC accession number PTA-4591 or an antigen binding fragment thereof.
- 2. A chimeric or humanized version of the mouse monoclonal antibody produced by clone 2B6, having ATCC accession number PTA-4591 or an antigen binding fragment thereof.
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3. A hybridoma cell line 2B6, having ATCC accession number PTA-4591.
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4. A pharmaceutical composition comprising (i) a therapeutically effective amount of a first antibody that is a chimeric or humanized version of the murine monoclonal antibody produced by clone 2B6, having ATCC accession number PTA-4591, or an antigen binding fragment thereof, (ii) a second cytotoxic antibody that specifically binds a cancer antigen;
- and (iii) a pharmaceutically acceptable carrier.
- View Dependent Claims (5, 6, 7, 8, 25, 26, 27)
- 9. A pharmaceutical composition comprising (i) a therapeutically effective amount of an antibody that is a chimeric or humanized version of the murine monoclonal antibody produced by clone 2B6, having ATCC accession number PTA-4591, or an antigen binding fragment thereof, and (ii) a pharmaceutically acceptable carrier.
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31. An isolated antibody, or antigen binding fragment thereof, comprising a light chain variable region and a heavy chain variable region from the murine monoclonal antibody produced by clone 2B6, having ATCC accession number PTA-4591.
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32. An isolated antibody, or antigen binding fragment thereof, comprising a light chain variable region from the murine monoclonal antibody produced by clone 2B6, having ATCC accession number PTA-4591 wherein said antibody comprises a variable domain that specifically binds the extracellular domain of Fcγ
- RIIB with greater affinity than said variable domain binds Fcγ
RIIA. - View Dependent Claims (35, 36, 37, 38, 39, 40)
- RIIB with greater affinity than said variable domain binds Fcγ
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33. An isolated antibody, or antigen binding fragment thereof, comprising a heavy chain variable region from the murine monoclonal antibody produced by clone 2B6, having ATCC accession number PTA-4591 wherein said antibody comprises a variable domain that specifically binds the extracellular domain of Fcγ
- RIIB with greater affinity than said variable domain binds Fcγ
RIIA.
- RIIB with greater affinity than said variable domain binds Fcγ
Specification