Spectroscopy of deeply-scattered light

• US 7,426,410 B2
• Filed: 06/06/2003
• Issued: 09/16/2008
• Est. Priority Date: 06/06/2003
• Status: Active Grant

• Current Assignee: Infraredx Incorporated (Nipro Corporation)
• Original Assignee: Infraredx Incorporated (Nipro Corporation)
• Inventors: Zuluaga, Andres, Dejesus, Stephen
• Primary Examiner(s): Casler; Brian
• Assistant Examiner(s): Cattungal; Sanjay
• Application Number:
  US10/456,979
• Publication Number:
  US 20040249289A1
• Time in Patent Office: 1,929 Days
• Field of Search: 600309-344, 600473-480, 600/407, 600/408, 606 1- 19
• US Class Current: 600/476
• CPC Class Codes: A61B 5/0062 Arrangements for scanning
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: G02B 23/26 using light guides for illumination G02B23/2469

Abstract

A spectroscope includes first and second beam redirectors in optical communication with first and second fibers respectively. The first and second beam redirectors are oriented to illuminate respective first and second areas. The second area is separated from the first area by a separation distance that exceeds the separation distance between the first and second beam redirectors.

Claims

1. A spectroscope comprising:

first and second fibers, one of which defines a longitudinal axis;

a first fixed beam-redirector in optical communication with the first fiber, the first beam-redirector being oriented to illuminate a first area having a center;

a second fixed beam-redirector in optical communication with the second fiber and axially separated along the longitudinal axis from the first beam-redirector by a first separation distance, the second beam-redirector being oriented to illuminate a second area having a center axially separated from the center of the first area along the longitudinal axis by a second separation distance that exceeds the first separation distance by a fixed amount.

2. The spectroscope of claim 1, wherein the first beam-redirector comprises a mirror.

3. The spectroscope of claim 1, wherein the first beam-redirector comprises a lens system.

4. The spectroscope of claim 3, wherein the first beam-redirector further comprises a mirror in optical communication with the lens system.

5. The spectroscope of claim 1, wherein the first beam-redirector comprises a distal portion of the first fiber, the distal portion being bent to illuminate the first area.

6. The spectroscope of claim 1, wherein the first beam-redirector comprises a diffracting element.

7. The spectroscope of claim 1, wherein the extent to which the second separation distance exceeds the first separation distance is chosen to enhance collection of light scattered from a target located at a selected distance from the first area.

8. The spectroscope of claim 1, further comprising a catheter through which the first and second fibers extend.

9. The spectroscope of claim 1, wherein

the first and second beam re-directors are oriented to define a pitch angle therebetween, the pitch angle being between 0 radians and π

radians; and

wherein

the first separation distance is slightly greater than an average fiber diameter but less than 3 millimeters.

10. The spectroscope of claim 1, wherein

the first and second beam re-directors are oriented to define a pitch angle therebetween, the pitch angle being between π

/2 radians and the smaller of the numerical apertures of the first and second fibers; and

wherein

the first separation distance is slightly greater than an average fiber diameter but less than 1.5 millimeters.

11. The spectroscope of claim 1, wherein

the first and second beam re-directors are oriented to define a pitch angle therebetween, the pitch angle being within a 0.5 radian window having a lower bound defined by the greater of the numerical apertures of the first and second fibers;

and wherein

the first separation distance is within a 0.5 millimeter window having a lower bound defined by a distance slightly greater than an average fiber diameter.

12. The spectroscope of claim 1, wherein

the first and second beam re-directors are oriented to define a pitch angle therebetween, the pitch angle being within a 0.1 radian window centered at the sum of the numerical apertures of the first and second fibers;

and wherein

the first separation distance is within a 0.1 millimeter interval having a lower bound that is 0.35 millimeters greater than an average fiber diameter.

13. The spectroscope of claim 1, wherein

the first and second beam re-directors are oriented to define a pitch angle therebetween, the pitch angle being between 0 and π

/2 radians; and

wherein

the first separation distance is between 0.25 millimeters and 3 millimeters.

14. The spectroscope of claim 1, wherein

the first and second beam re-directors are oriented to define a pitch angle therebetween, the pitch angle being between 0.12 radians and π

/2 radians; and

wherein

the first separation distance is between 0.25 millimeters and 1.5 millimeters.

15. The spectroscope of claim 1, wherein

the first and second beam re-directors are oriented to define a pitch angle therebetween, the pitch angle being between 0.25 and 0.75 radians;

and wherein

the first separation distance is between 0.25 millimeters and 0.75 millimeters.

16. The spectroscope of claim 1, wherein at least one of the first and second fibers comprises an optical fiber having a numerical aperture of 0.12 radians and a core diameter selected from the group consisting of 9 micrometers, 100 micrometers, and 200 micrometers.

17. The spectroscope of claim 1, wherein at least one of the first and second fibers comprises an optical fiber having a numerical aperture of 0.22 radians and a core diameter selected from the group consisting of 100 micrometers or 200 micrometers.

18. The spectroscope of claim 1, wherein at least one of the first and second fibers comprises an optical fiber having a numerical aperture of 0.275 radians and a core diameter of 62.5 micrometers.

19. A method for collecting light scattered from behind an arterial wall, the method comprising:

providing an illumination beam redirector and a collection beam redirector axially separated from each other by a first distance along a longitudinal axis;

illuminating an illumination spot on the arterial wall, the illumination spot having a center;

pointing a collection-beam redirector toward a collection spot, the collection spot having a center axially separated along the longitudinal axis from the center of the illumination spot by a second distance that exceeds the first distance by a fixed amount; and

recovering scattered light incident on the collection-beam redirector.

20. The method of claim 19, wherein pointing a collection-beam redirector comprises orienting a collection mirror to receive light from the collection spot.

21. The method of claim 19, wherein pointing a collection beam redirector comprises providing a lens to direct light received from the collection spot.

22. The method of claim 19, wherein pointing a collection beam redirector comprises orienting an end of an optical fiber to receive light from the collection spot.

23. The method of claim 19, wherein pointing a collection beam redirector comprises:

selecting a depth from which to collect the scattered light; and

pointing the collection-beam redirector in a direction that enhances the amount of light received from the selected depth.

24. A method for collecting light scattered from behind an arterial wall, the method comprising:

providing an illumination beam redirector and a collection beam redirector axially separated from each other by a first distance along a longitudinal axis;

pointing the collection-beam redirector at a collection spot on the wall;

pointing the delivery-beam redirector toward an illumination spot on the wall in a direction away from the collection spot;

passing light through the delivery-beam redirector; and

recovering scattered light incident on the collection-beam redirector

wherein a center of the collection spot and a center of the illumination spot are axially separated from each other along the longitudinal axis by a second distance that exceeds the first distance by a fixed amount.

25. The method of claim 24, wherein pointing a delivery-beam redirector comprises orienting a delivery mirror to direct light toward the illumination spot.

26. The method of claim 24, wherein pointing a delivery-beam redirector comprises providing a lens to direct light toward the illumination spot.

27. The method of claim 24, wherein pointing a delivery-beam redirector comprises orienting an end of an optical fiber to direct light toward the illumination spot.

28. The method of claim 24, wherein pointing a delivery-beam redirector comprises:

selecting a depth from which to collect the scattered light; and

pointing the delivery-beam redirector in a direction that enhances the amount of light received from the selected depth.

29. A spectroscope comprising:

first and second fibers, one of which defines a longitudinal axis;

a first fixed beam-redirector in optical communication with the first fiber, the first beam-redirector being oriented to illuminate a first area;

a second fixed beam-redirector in optical communication with the second fiber the second beam-redirector being oriented to illuminate a second area axially separated from the first area along the longitudinal axis by an axial separation distance that increases with distance from the spectroscope.