Analyte concentration detection devices and methods
First Claim
1. An arrangement for use in detecting the presence or concentration of an analyte present in bodily fluid, the arrangement comprising:
- (a) an assay pad adapted to receive a sample of the bodily fluid, the assay pad containing a reagent;
(b) an array of CMOS detectors, each detector adapted to produce a signal indicative of a reaction between the analyte and the reagent; and
(c) electronics monitoring and interpreting the signals produced by the detectors to estimate the volume of the sample under analysis based on the number of CMOS detectors producing a signal indicative of the reaction between the analyte and the reagent.
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Accused Products
Abstract
Arrangements for the detection of the presence and/or concentration of an analyte in a sample of bodily fluid include diffuse transmission, diffuse reflection and edge or waveguide illumination arrangements. A vertical flow assay arrangement and/or technique is also disclosed, and includes a detection component that can be in the form of an array of optical detection elements. A number of assay pad constructions are described which may include at least one or more of the following components: a prefilter component, a reflective component, a membrane component, a reagent component, a mesh component, and a component to prevent lateral spreading.
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Citations
18 Claims
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1. An arrangement for use in detecting the presence or concentration of an analyte present in bodily fluid, the arrangement comprising:
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(a) an assay pad adapted to receive a sample of the bodily fluid, the assay pad containing a reagent; (b) an array of CMOS detectors, each detector adapted to produce a signal indicative of a reaction between the analyte and the reagent; and (c) electronics monitoring and interpreting the signals produced by the detectors to estimate the volume of the sample under analysis based on the number of CMOS detectors producing a signal indicative of the reaction between the analyte and the reagent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method useful in detecting the presence or concentration of an analyte present in bodily fluid, the method comprising:
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(a) introducing a sample of the bodily fluid onto an assay pad, the assay pad containing a reagent; (b) monitoring a reaction between the analyte and the reagent, comprising an array of CMOS detectors wherein at least one CMOS detector provides a signal in response to the reaction; and (c) monitoring and interpreting the at least one signal to provide an estimate of the volume of the sample under analysis based on the number of CMOS detectors producing a signal indicative of the reaction between the analyte and the reagent. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18)
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Specification