Quorum sensing and biofilm formation
First Claim
1. A method of inhibiting or treating the formation of a biofilm comprising S. mutans on a surface, said method comprising contacting the surface with autoinducer-2 in an amount effective to increase Lux-S dependent signal pathway in a bacterium.
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Abstract
The present invention is based on the discovery that interspecies quorum sensing is related to biofilm formation. The present invention provides methods useful for treating or preventing biofilm formation and microbial infections associated with biofilm formation by using an agent that either increases LuxS-dependent pathway or interspecies quorum sensing signal. The present invention also provides compositions containing an anti-microbial agent and an agent that either increases LuxS-dependent pathway or interspecies quorum sensing signal.
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Citations
27 Claims
- 1. A method of inhibiting or treating the formation of a biofilm comprising S. mutans on a surface, said method comprising contacting the surface with autoinducer-2 in an amount effective to increase Lux-S dependent signal pathway in a bacterium.
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9. A method of inhibiting or treating the formation of a biofilm comprising S. mutans on a surface, said method comprising contacting the surface with autoinducer-2 in an amount effective to increase an interspecies quorum sensing signal.
- 10. A method of treating a condition associated with formation of a biofilm comprising S. mutans, said method comprising administering to a subject in need of such treatment autoinducer-2 in an amount effective to increase LuxS-dependent signal pathway in a bacterium.
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15. A method of treating a condition associated with formation of a biofilm comprising S. mutans, said method comprising administering to a subject in need of such treatment autoinducer-2 in an amount effective to increase an interspecies quorum sensing signal.
- 16. A method of treating a condition associated with formation of a biofilm comprising S. mutans, said method comprising administering to a subject in need of such treatment a composition comprising an anti-microbial agent and autoinducer-2 in an amount effective to increase LuxS-dependent signal pathway in a bacterium.
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21. A method of treating a condition associated with formation of a biofilm comprising S. mutans, said method comprising administering to a subject in need of such treatment a composition comprising an anti-microbial agent and autoinducer-2 in an amount effective to increase an interspecies quorum sensing signal.
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22. A method of treating a microbial infection associated with formation of a biofilm comprising S. mutans, said method comprising administering to a population of bacteria an anti-microbial agent and autoinducer-2 in an amount effective to increase LuxS-dependent signal pathway in a bacterium.
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23. A method of treating microbial infection associated with formation of a biofilm comprising S. mutans, said method comprising administering to a population of bacteria an anti-microbial agent and autoinducer-2 in an amount effective to increase interspecies quorum sensing signal.
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24. A method of treating formation of a biofilm comprising S. mutans on a surface comprising contacting the surface, said method with an anti-microbial agent and autoinducer-2 in an amount effective to increase LuxS-dependent signal pathway in a bacterium.
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25. A method of treating formation of a biofilm comprising S. mutans on a surface comprising contacting the surface, said method with an anti-microbial agent and autoinducer-2 in an amount effective to increase interspecies quorum sensing signal.
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26. A method of sensitizing bacteria for an anti-bacteria treatment comprising administering to a biofilm population of bacteria comprising S. mutans an amount of autoinducer-2 effective to increase LuxS-dependent signal pathway in a bacterium.
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27. A method of sensitizing bacteria for an anti-bacteria treatment comprising administering to a biofilm population of bacteria comprising S. mutans an amount of autoinducer-2 effective to increase, interspecies quorum sensing signal.
Specification