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Quantitative broadband absorption and scattering spectroscopy in turbid media by combined frequency-domain and steady state methodologies

  • US 7,428,434 B2
  • Filed: 07/09/2002
  • Issued: 09/23/2008
  • Est. Priority Date: 07/27/2001
  • Status: Active Grant
First Claim
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1. A method of analyzing turbid media comprising:

  • performing frequency-domain photon migration measurements on a turbid medium sample at a plurality of specified wavelengths for determining absolute photon absorption coefficient values and absolute photon scattering coefficient values of the turbid medium at such discrete wavelengths;

    performing steady-state measurements on the same turbid medium sample for determining a relative spectrum for the sample;

    calibrating the relative spectrum obtained from the steady-state measurements in accordance with the discrete absorption and scattering coefficient values obtained from the frequency-domain measurements;

    determining a scattering coefficient spectrum from the discrete scattering coefficient values obtained from the frequency-domain measurements; and

    combining calibrated spectrum values and scattering coefficient spectrum values to obtain an absorption coefficient spectrum for the turbid medium sample.

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