Magnetoacoustic sensor system and associated method for sensing environmental conditions

• US 7,429,127 B2
• Filed: 04/23/2003
• Issued: 09/30/2008
• Est. Priority Date: 04/25/2002
• Status: Expired due to Fees

• Current Assignee: Glaxo Group Limited (Glaxosmithkline Holdings Ltd.)
• Original Assignee: Glaxo Group Limited (Glaxosmithkline Holdings Ltd.)
• Inventors: Walker, Dwight Sherod, James, Michael Bernard
• Primary Examiner(s): Verbitsky; Gail
• Application Number:
  US10/512,268
• Publication Number:
  US 20060050765A1
• Time in Patent Office: 1,987 Days
• Field of Search: 374/16, 374/28, 374/109, 374117-119, 374/141, 374/142, 374/208, 374/163, 374/21, 738/659, 73/73, 340/604
• US Class Current: 374/109
• CPC Class Codes: G01K 11/26 of resonant frequencies
• CPC Class Codes: G01K 7/32 using change of resonant frequency of a crystal
• CPC Class Codes: G01K 7/36 using magnetic elements, e.g. magnets, coils magnetic elements per se H01F
• CPC Class Codes: G01N 2291/02845 Humidity, wetness
• CPC Class Codes: G01N 2291/02881 Temperature
• CPC Class Codes: G01N 2291/0423 Surface waves, e.g. Rayleigh waves, Love waves
• CPC Class Codes: G01N 29/036 by measuring frequency or resonance of acoustic waves
• CPC Class Codes: G01N 29/2412 using the magnetostrictive properties of the material to be examined, e.g. electromagnetic acoustic transducers [EMAT]; investigating the presence of flaws using eddy currents G01N27/90, magnetostrictive transducers B06B1/08, measuring magnetostrictive properties G01R33/18
• CPC Class Codes: G01N 33/15 Medicinal preparations ; Physical properties thereof, e.g. dissolubility drug screening with animal cells G01N33/5008
• CPC Class Codes: G01N 5/025 for determining moisture content

Abstract

A remote sensor system (60) and method for passively sensing environmental conditions, such as temperature and humidity, uses a magnetic impulse from an AC interrogation coil (68) to stimulate a magnetoelastic sensor (62) to generate an acoustic signal (AE) at the resonant frequency of the magnetoelastic sensor (62). The acoustic signal (AE) is received by amplifier (74), detected and displayed (76). The systems and methods are particularly suited for detecting environmental conditions in commercial pharmaceutical packaging, such as blister packs.

Claims

1. A packaging assembly for sensing an environmental condition within pharmaceutical packaging, comprising:

a base sheet having at least one pocket formed therein and being adapted such that a pharmaceutical composition is contained therein, wherein said pharmaceutical composition is an inhalable dry powder composition;

a lid sheet, said lid sheet including a pocket portion, said pocket portion being disposed proximate said pocket and wherein said lid sheet is bonded to said base sheet to form a sealed blister pack; and

a sensor element comprising a material that is responsive to said environmental condition and having a magnetoelastic resonant frequency in the range of 300-700 kHz, said sensor element generating at least a first acoustic signal at said resonant frequency in response to an AC magnetic pulse, said sensor element being present within said sealed blister pack and attached to said pocket portion of said lid sheet within said pocket and configured to measure environmental conditions within said said sealed blister pack.

2. The packaging assembly of claim 1, wherein said sensor element includes first and second ends.

3. The packaging assembly of claim 2, wherein said first end of said sensor element is attached to said lid sheet pocket portion.

4. The packaging assembly of claim 1, wherein said sensor element includes a support adapted to engage said lid sheet pocket portion.

5. The packaging assembly of claim 4, wherein said first end of said sensor element is secured to said support whereby said second end of said sensor element is cantilevered.

6. The packaging assembly of claim 1, wherein said assembly includes an interrogation coil adapted to provide said AC magnetic pulse to said sensor element to generate said first acoustic signal.

7. The packaging assembly of claim 1, wherein said assembly further includes a receiver adapted to detect said first acoustic signal.

8. The packaging assembly of claim 1, wherein said sensor element comprises a magnetoelastic alloy.

9. The packaging assembly of claim 8, wherein said magnetoelastic alloy comprises a material selected from the group consisting of iron, cobalt, samarium, yttrium, gadolinium, terbium and dysprosium.

10. The packaging assembly of claim 8, wherein said magnetoelastic alloy comprises an iron based, amorphous metallic glass alloy.

11. The packaging assembly of claim 10, wherein said iron based, amorphous metallic glass alloy comprises Metglass™

2826.

12. The packaging assembly of claim 1, wherein said environmental condition comprises temperature.

13. The packaging assembly of claim 1, wherein said sensor element is coated with a moisture sensitive material.

14. The packaging assembly of claim 13, wherein said moisture sensitive material exhibits a change in mass in response to a change in a second environmental condition.

15. The packaging assembly of claim 14, wherein said second environmental conditions comprises humidity.

16. The packaging assembly of claim 13, wherein said moisture sensitive material comprises 1,4-phenyl-bridged polysilsesquioxane.

17. The packaging assembly of claim 1, wherein said packaging assembly further includes a memory adapted to receive and store at least said first acoustic signal, a processor for determining at least a first environmental condition value using said first acoustic signal, and a display.