Kits for assays of rapid screening of diabetes
First Claim
1. A kit for rapid screening of diabetes, the kit comprising:
- a glucose-sensing ophthalmic device and instructions for using the glucose-sensing ophthalmic device to screen for diabetes, wherein the glucose-sensing ophthalmic device comprises a testing agent composition which specifically and reversibly interacts with glucose to form a detectable optical signal which changes in a concentration-dependent manner, wherein the testing agent composition comprises a receptor having a first label associated therewith and a competitor having a second label associated therewith, wherein one of the first and second labels is a fluorescent energy donor and the other one is a fluorescent or non-fluorescent energy acceptor, wherein the ophthalmic device comprises a glucose-sensing layer-by-layer coating which is not covalently attached to the core material of the ophthalmic device, and wherein the glucose-sensing layer-by-layer coating comprises one or more layers of a vesicle with a charged surface and with the receptor and the competitor entrapped therein.
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Accused Products
Abstract
The invention provides an in vivo screening assay and an in vitro screening assay for rapid screening of diabetes. A method of the invention includes determining a first glucose concentration in an ocular fluid of a patient; administering orally a load of carbohydrate to the patient; determining a second glucose concentration in an ocular fluid of the patient at a period of time of less than 50 minutes after orally administering of the load of carbohydrate; comparing the second glucose concentration with the first glucose concentration to determine if the patient is likely to be a diabetic. The method of the invention is performed by using a kit of the invention. The kit comprises: (1) a glucose-sensing ophthalmic device and instructions for using the glucose-sensing ophthalmic device to screen for diabetes; or (2) two or more tear-collecting devices, and a testing agent composition which specifically reacts with glucose to form a detectable signal. The glucose-sensing ophthalmic device comprises a testing agent composition which specifically and reversibly interacts with glucose to form a detectable optical signal which changes in a concentration-dependent manner.
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Citations
3 Claims
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1. A kit for rapid screening of diabetes, the kit comprising:
- a glucose-sensing ophthalmic device and instructions for using the glucose-sensing ophthalmic device to screen for diabetes, wherein the glucose-sensing ophthalmic device comprises a testing agent composition which specifically and reversibly interacts with glucose to form a detectable optical signal which changes in a concentration-dependent manner, wherein the testing agent composition comprises a receptor having a first label associated therewith and a competitor having a second label associated therewith, wherein one of the first and second labels is a fluorescent energy donor and the other one is a fluorescent or non-fluorescent energy acceptor, wherein the ophthalmic device comprises a glucose-sensing layer-by-layer coating which is not covalently attached to the core material of the ophthalmic device, and wherein the glucose-sensing layer-by-layer coating comprises one or more layers of a vesicle with a charged surface and with the receptor and the competitor entrapped therein.
- View Dependent Claims (2, 3)
Specification