Process for analyzing tear fluid
First Claim
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1. A process for analyzing at least one analyte contained in tear fluid which is present in a hydrogel contact lens which has been worn on the eye, wherein the hydrogel is a polymer, comprising the steps of:
- (a) chemically inducing a reduction in the volume of the hydrogel lens by crosslinking the polymer, thereby squeezing tear fluid that contains the at least one analyte from the polymer; and
(b) contacting the tear fluid that contains the at least one analyte according to step (a) with an analytical instrument to detect the analyte.
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Abstract
The present invention concerns a process for analyzing an analyte in a hydrogel contact lens following its wear on the eye, comprising the steps of
- (a) physically or chemically inducing a volume reduction of the hydrogel contact lens and thereby squeezing the analyte out of the polymer material making up the contact lens and
- (b) feeding the analyte obtained according to step (a) into an analyzer.
The process of the invention provides a new concept for noninvasively measuring various analytes occurring in the tear fluid that is comfortable to the user.
72 Citations
12 Claims
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1. A process for analyzing at least one analyte contained in tear fluid which is present in a hydrogel contact lens which has been worn on the eye, wherein the hydrogel is a polymer, comprising the steps of:
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(a) chemically inducing a reduction in the volume of the hydrogel lens by crosslinking the polymer, thereby squeezing tear fluid that contains the at least one analyte from the polymer; and (b) contacting the tear fluid that contains the at least one analyte according to step (a) with an analytical instrument to detect the analyte. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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Specification