Multiwell plates with integrated biosensors and membranes
First Claim
Patent Images
1. A multiwell plate comprising:
- (a) a colorimetric resonant reflectance biosensor or a grating-based waveguide biosensor;
(b) a first liquid impermeable sheet of a thickness of about 5 μ
m to about 1,000 μ
m, wherein the first liquid impermeable sheet has two or more holes;
wherein the first liquid impermeable sheet is attached to a top surface of the colorimetric resonant reflectance biosensor or the grating-based waveguide biosensor;
(c) a membrane attached to the top of the first liquid impermeable sheet, wherein the membrane covers all of the holes of the first liquid impermeable sheet;
(d) a multiwell plate frame attached to the top of the membrane, wherein the multiwell plate frame has two or more holes and wherein the holes have a same size, number, and position as in the first liquid impermeable sheet such that a multiwell plate with an upper chamber and a lower chamber is formed by the colorimetric resonant reflectance biosensor or the grating-based waveguide biosensor, the first liquid impermeable sheet, the membrane, and the multiwell plate frame.
2 Assignments
0 Petitions
Accused Products
Abstract
The invention provides compositions and methods of detecting binding of molecules to a biosensor. Compositions of the invention comprise a multiwell plate with an integrated biosensor and a membrane.
155 Citations
11 Claims
-
1. A multiwell plate comprising:
-
(a) a colorimetric resonant reflectance biosensor or a grating-based waveguide biosensor; (b) a first liquid impermeable sheet of a thickness of about 5 μ
m to about 1,000 μ
m, wherein the first liquid impermeable sheet has two or more holes;
wherein the first liquid impermeable sheet is attached to a top surface of the colorimetric resonant reflectance biosensor or the grating-based waveguide biosensor;(c) a membrane attached to the top of the first liquid impermeable sheet, wherein the membrane covers all of the holes of the first liquid impermeable sheet; (d) a multiwell plate frame attached to the top of the membrane, wherein the multiwell plate frame has two or more holes and wherein the holes have a same size, number, and position as in the first liquid impermeable sheet such that a multiwell plate with an upper chamber and a lower chamber is formed by the colorimetric resonant reflectance biosensor or the grating-based waveguide biosensor, the first liquid impermeable sheet, the membrane, and the multiwell plate frame. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
-
Specification