Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
First Claim
1. A method of treating or reducing vaginal dryness comprising increasing levels of a sex steroid precursor selected from the group consisting of dehydroepiandrosterone, dehydroepiandrosterone sulfate, androst-5-ene-3b,17b-diol and 4-androsten-3,17-dione, in a patient in need thereof by administering a therapeutically effective amount of the precursor and further comprising administering a therapeutically effective amount of a selective estrogen receptor modulator as part of a combination therapy.
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Abstract
Novel methods for the medical treatment and/or inhibition of the development of osteoporosis, breast cancer, hypercholesterolemia, hyperlipidemia or atherosclerosis in susceptible warm-blooded animals including humans involving administration of selective estrogen receptor modulator particularly compounds having the general structure:
and an amount of a sex steroid precursor selected from the group consisting of dehydroepiandrosterone, dehydroepiandrosterone sulfate, androst-5-ene-3β, 17β-diol and compounds converted in vivo to one of the foregoing presursor. Further administration of bisphosphonates in combination with selective estrogen receptor modulators and/or sex steroid precursor is disclosed for the medical treatment and/or inhibition of the development of osteoporosis. Pharmaceutical compositions for delivery of active ingredient(s) and kit(s) useful to the invention are also disclosed.
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1 Claim
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1. A method of treating or reducing vaginal dryness comprising increasing levels of a sex steroid precursor selected from the group consisting of dehydroepiandrosterone, dehydroepiandrosterone sulfate, androst-5-ene-3b,17b-diol and 4-androsten-3,17-dione, in a patient in need thereof by administering a therapeutically effective amount of the precursor and further comprising administering a therapeutically effective amount of a selective estrogen receptor modulator as part of a combination therapy.
Specification