Antibodies to human tumor necrosis factor receptor-like 2
First Claim
Patent Images
1. An isolated antibody which specifically binds to a polypeptide consisting of amino acids −
- 38 to 245 of SEQ ID NO;
26.
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Abstract
The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding a human TR2 receptor and two splice variants thereof. TR2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR2 receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant states related to aberrant proliferation and differentiation of cells which express the TR2 receptors.
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Citations
41 Claims
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1. An isolated antibody which specifically binds to a polypeptide consisting of amino acids −
- 38 to 245 of SEQ ID NO;
26. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 12, 13, 14, 15)
- 38 to 245 of SEQ ID NO;
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9. An isolated antibody which binds to a polypeptide consisting of amino acids −
- 38 to 162 of SEQ ID NO;
26. - View Dependent Claims (10, 11)
- 38 to 162 of SEQ ID NO;
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16. An isolated antibody which specifically binds to a polypeptide consisting of amino acids −
- 38 to 162 of SEQ ID NO;
26. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
- 38 to 162 of SEQ ID NO;
- 28. An isolated antibody which specifically binds to a polypeptide consisting of amino acids 1 to 162 of SEQ ID NO:
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40. An isolated antibody which binds to a polypeptide having the sequence of SEQ ID NO:
- 26.
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41. An isolated antibody that immunospecifically binds a tumor necrosis factor receptor, wherein said receptor comprises a polypeptide having the sequence of SEQ ID NO:
- 26.
Specification