Noninvasive blood analysis by optical probing of the veins under the tongue

• US 7,430,445 B2
• Filed: 04/26/2004
• Issued: 09/30/2008
• Est. Priority Date: 04/24/2003
• Status: Active Grant

• Current Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Original Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Inventors: Esenaliev, Rinat O., Prough, Donald S.
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US10/554,149
• Publication Number:
  US 20060195021A1
• Time in Patent Office: 1,618 Days
• Field of Search: 600/310, 600/322, 600/323, 600/340, 600/344
• US Class Current: 600/344
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/0068 Confocal scanning
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14535 for measuring haematocrit
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/682 Mouth, e.g., oral cavity; tongue; Lips; Teeth

Abstract

A method for analysis of blood components or parameters is disclosed where a probe having an excitation outlet and a response inlet is placed in proximity to or in contact with a tissue of an underside of a patient'"'"'s tongue over a big vein in the tongue so that an excitation signal exits the outlet, produces a response which enters the inlet for detection and analysis.

Claims

1. An apparatus for noninvasive blood analysis comprising:

right side and left side sections adapted to engage one or more teeth on each of a right side and left side of a patient'"'"'s jaw,

two transition sections extending downwardly from each of the side sections,

a middle section interposed between the two transition sections adapted to be proximate to or in contact with an underside of a patient'"'"'s tongue, where the middle section includes;

a emitter, and

a receiver,

where the emitter and the receiver are adapted to be proximate or in contact with a surface of a tissue over a big vein associated with an underside of the patient'"'"'s tongue;

a light generation/delivery system including a light source capable of generating at least one frequency of light, and a light conduit interconnecting the light source with a radiation outlet, where the system is adapted to deliver radiation to blood in the big vein; and

a detector/analyzer system including a detector adapted to detect a response from the irradiated blood via a response inlet and an analyzer adapted to convert the detected response into a concentration of a blood component and/or a value of a parameter of the blood.

2. The apparatus of claim 1, further comprising:

a plurality of emitters and receivers, located in pairs on a right hand side and a left side of the middle section.

3. The apparatus of claim 1, further comprising:

a display adapted to display the response, the concentration, and/or the value.

4. The apparatus of claim 1, wherein the wavelength of the radiation is from about 200 nanometers to about 20 microns.

5. The apparatus of claim 1, wherein the radiation comprises a plurality of wavelengths or frequencies.

6. The apparatus of claim 1, wherein the detector is capable of detecting data derived from one or a combination of techniques selected from the group consisting of reflectance technique, confocal technique, scanning confocal technique, polarization techniques, interferometry, optoacoustics, low coherence interferometry and reflectometry, techniques based on speckle measurements, fluorescence technique, Raman scattering technique, and two ormulti-photon techniques.

7. The apparatus of claim 1, wherein the response corresponds to hemoglobin and the wavelength is selected from the group consisting of 548 nm, 568 nm, 587 nm, 805 nm, from about 400 nm to about 640 nm and from about 1120 nm to about 1130 nm.

8. The apparatus of claim 1, wherein the blood component is selected from the group consisting of hematocrit, hemoglobin, glycosylated hemoglobin, hemoglobin and glycosylated hemoglobin, glucose, cholesterol, oxy-hemoglobin, deoxy-hemoglobin, and carboxy-hemoglobin.

9. The apparatus of claim 1, wherein the blood component is an exogenous substance selected from the group consisting of a drug, a dye or other reporter in molecular state or a particle made of liquid, gas, or solid material including polymer, metal, semiconductor, dielectric, or a combination of liquid, gas, or solid materials, and a layered structure.

10. The apparatus of claim 9, wherein the exogenous substance is selected from the group consisting of indocyanine green and Evans blue.

11. The apparatus of claim 9, wherein the exogenous substance are particles having a size from about 0.1 nanometer to about 10 microns.

12. The apparatus of claim 1, wherein the radiation is selected from the group consisting of microwave radiation, radio frequency radiation, ultrasound radiation, and low-frequency electromagnetic radiation.

13. The apparatus of claim 1, further comprising:

a device for generating a static electric or magnetic field.