Vascular prosthesis

• US 7,431,733 B2
• Filed: 06/28/2004
• Issued: 10/07/2008
• Est. Priority Date: 06/27/2003
• Status: Expired

• Current Assignee: University of South Florida (State University System of Florida)
• Original Assignee: University of South Florida (State University System of Florida)
• Inventors: Knight, Joseph Allen
• Primary Examiner(s): GHERBI, SUZETTE JAIME J
• Application Number:
  US10/561,929
• Publication Number:
  US 20060271167A1
• Time in Patent Office: 1,562 Days
• Field of Search: 623 21- 238
• US Class Current: 623/2.1
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61F 2/2412 with soft flexible valve members, e.g. tissue valves shaped like natural valves check valves with flexible valve members in general F16K15/14
• CPC Class Codes: A61F 2/2476 Valves implantable in the body not otherwise provided for
• CPC Class Codes: A61F 2002/061 provided with means for allowing access to secondary lumens

Abstract

The subject invention concerns vascular prosthetic devices and methods for ascending aorta and/or valve replacement in humans and animals. In one embodiment, a device of the invention includes a vessel-like structure having a first end adapted for surgical attachment to a left ventricle, a second end adapted for surgical attachment to an aorta, and, interposed between the first and second ends, a sinus portion configured in the shape of the sinuses of Valsalva in a human aortic valve.

Claims

1. A prosthesis comprising:

a vessel-like structure having a first end adapted for surgical attachment to a left ventricle, a second end adapted for surgical attachment to an aorta, and, interposed between the first and second ends, a sinus portion configured in the shape of the sinuses of Valsalva in a human aortic valve, wherein said vessel-like structure is composed of a synthetic material, and wherein said sinus portion comprises an ostium and attached to said ostium is an ostium attachment ring.

2. The prosthesis according to claim 1, wherein an artificial vessel is connected to said ostium.

3. The prosthesis according to claim 1, wherein said sinus portion comprises three sinus cavities.

4. The prosthesis according to claim 3, wherein at least two of said sinus cavities each comprise an ostium.

5. The prosthesis according to claim 4, wherein said ostium is located at a position on said sinus for optimal fluid dynamics and blood flow.

6. The prosthesis according to claim 5, wherein said ostium is located about 10 to 20 mm from the base of said sinus.

7. The prosthesis according to claim 5, wherein said ostium is located about 12 to 18 mm from the base of said sinus.

8. The prosthesis according to claim 5, wherein said ostium is located about 14 to 16 mm from the base of said sinus.

9. The prosthesis according to claim 5, wherein said ostium is located about 15 mm from the base of said sinus.

10. The prosthesis according to claim 4, wherein an artificial vessel is connected to said ostium.

11. The prosthesis according to claim 1, wherein said vessel-like structure further comprises a valve for regulating fluid flow.

12. The prosthesis according to claim 11, wherein said valve comprises animal tissue.

13. The prosthesis according to claim 11, wherein said valve does not comprise animal tissue.

14. The prosthesis according to claim 13, wherein said valve is a caged ball valve, a tilting disc valve, a bileaflet valve, or a trileaflet valve.

15. The prosthesis according to claim 1, wherein said first end or said second end or both said first end and said second end of said vessel-like structure comprise a sewing ring.

16. The prosthesis according to claim 15, wherein said sewing ring comprises a biocompatible elastomeric material.

17. The prosthesis according to claim 15, wherein said sewing ring comprises a polymer material.

18. The prosthesis according to claim 17, wherein said polymer material is covered with a woven biocompatible material.

19. The prosthesis according to claim 1, wherein an artificial or a non-artificial vessel is connected to said ostium attachment ring.

20. The prosthesis according to claim 1, wherein said ostium is located at a position on said sinus for optimal fluid dynamics and blood flow.

21. The prosthesis according to claim 20, wherein said ostium is located about 10 to 20 mm from the base of said sinus.

22. The prosthesis according to claim 20, wherein said ostium is located about 12 to 18 mm from the base of said sinus.

23. The prosthesis according to claim 20, wherein said ostium is located about 14 to 16 mm from the base of said sinus.

24. The prosthesis according to claim 20, wherein said ostium is located about 15 mm from the base of said sinus.

25. The prosthesis according to claim 1, wherein said vessel-like structure or a portion thereof is composed of a material selected from the group consisting of stainless steel, titanium, chromium, a metal alloy, polycarbonate polymer, polysulfone, polyurethane, polytetrafluoroethylene, and a blend of polyurethane and polysiliconurethane.

26. The prosthesis according to claim 1, wherein said vessel-like structure or a portion thereof comprises a coating to render said structure more biocompatible.

27. The prosthesis according to claim 1, wherein said vessel-like structure or a portion thereof comprises a coating comprising one or more compositions selected from the group consisting of an antibiotic, anticoagulant, antitlirombogenic, antiproliferative, antiplatelet, antiinflammatory, antioxidant, and a pharmaceutical agent.

28. The prosthesis according to claim 1, wherein said vessel-like structure or a portion thereof comprises a coating to render said structure more hemostatic.

29. A method for replacing an ascending aorta in a human or animal, the method comprising the step of:

a) removing the ascending aorta present in the human or animal; and

b) implanting the prosthesis of claim 1 into the human or animal.