Delivery of multiple doses of medications
DCFirst Claim
1. A solid dosage form comprising d-threo methylphenidate or salt thereof providing a plasma concentration profile of said d-threo methylphenidate or salt thereof comprising two maxima temporally separated by from about two hours to about seven hours, said solid dosage form comprising:
- (a) a first group of particles comprising from about 2% to about 99% by weight of d-threo methylphenidate or salt thereof; and
(b) a second group of particles comprising coated particles, said coated particles comprising from about 2% to about 75% by weight of d-threo methylphenidate or salt thereof in admixture with one or more binders and a coating comprising an ammonio methacrylate copolymer.
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Abstract
Dosage forms for oral administration of a methylphenidate drug are provided. The dosage forms provide a substantially immediate dose of methylphenidate upon ingestion, followed by one or more additional doses at predetermined times. By providing such a drug release profile, the dosage forms eliminate the need for a patient to carry an additional dose for ingestion during the day. The dosage forms and methods provided are useful in administering methylphenidate and pharmaceutically acceptable salts thereof, which generally require one or more doses throughout the day.
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Citations
6 Claims
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1. A solid dosage form comprising d-threo methylphenidate or salt thereof providing a plasma concentration profile of said d-threo methylphenidate or salt thereof comprising two maxima temporally separated by from about two hours to about seven hours, said solid dosage form comprising:
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(a) a first group of particles comprising from about 2% to about 99% by weight of d-threo methylphenidate or salt thereof; and (b) a second group of particles comprising coated particles, said coated particles comprising from about 2% to about 75% by weight of d-threo methylphenidate or salt thereof in admixture with one or more binders and a coating comprising an ammonio methacrylate copolymer. - View Dependent Claims (2, 3, 4, 5, 6)
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Specification