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Crystallization of IGF-1

  • US 7,433,788 B2
  • Filed: 06/20/2006
  • Issued: 10/07/2008
  • Est. Priority Date: 02/09/2001
  • Status: Expired due to Fees
First Claim
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1. A method of identifying an agonist or antagonist of insulin-like growth factor 1 (IGF-1) of SEQ ID NO:

  • 1, comprising (i) obtaining a crystal formed by said IGF-1 of SEQ ID NO;

    1 that diffracts x-ray radiation to produce a diffraction pattern representing the three-dimensional structure of the IGF-1 of SEQ ID NO;

    1, including a receptor binding region comprising residues Tyr24, Thr29, Tyr31, and Tyr60 of said IGF-1 of SEQ ID NO;

    1, and has approximately the following cell constants a=31.831 Å

    , b=71.055 Å

    , c=65.995 Å

    , and a space group of C2221, and α





    , (ii) employing said three-dimensional structure to identify a compound that has a receptor-binding region that assumes the structure of or binds to said receptor binding region, and (iii) confirming that said compound acts as an IGF-1 agonist or antagonist thereby identifying said agonist or antagonist.

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