Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents

• US 7,435,788 B2
• Filed: 12/19/2003
• Issued: 10/14/2008
• Est. Priority Date: 12/19/2003
• Status: Expired due to Fees

• Current Assignee: Advanced Cardiovascular Systems Incorporated
• Original Assignee: Advanced Cardiovascular Systems Incorporated
• Inventors: Pacetti, Stephen D.
• Primary Examiner(s): Woodward; Ana L
• Application Number:
  US10/741,214
• Publication Number:
  US 20050137381A1
• Time in Patent Office: 1,761 Days
• Field of Search: 528/288, 528/291, 528/292, 528/300, 528/308, 528/308.6, 528/335, 528/340, 424/423
• US Class Current: 528/288
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 39/06 Free radical scavengers or antioxidants
• CPC Class Codes: A61P 7/02 Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
• CPC Class Codes: C08G 69/44 Polyester-amides
• CPC Class Codes: Y10T 428/31551 Of polyamidoester [polyurethane, polyisocyanate, polycarbamate, etc.]
• CPC Class Codes: Y10T 428/31725 Of polyamide

Abstract

This disclosure covers polymers, some of which are useful in medical device applications. The polymers comprise at least two different blocks, at least one L1 block with the formula

and at least one L2 block with the formula

Medical devices comprising these polymers, mixtures of these polymers with therapeutic agents, and methods of making these polymers and mixtures are within the scope of this disclosure. Some of these medical devices are implantable within a mammalian body, such as in a body lumen.

Claims

1. A polymer consisting of two different blocks,

wherein the blocks-comprise at least one L1 block and at least one L2 block and are selected from

a) at least one L1 block with the formula

2. The polymer of claim 1 wherein R includes oligomers of ethylene glycol, propylene glycol (1,2- and 1,3-substituted isomers), tetramethylene glycol (1,2-, 1,3-, 1,4-, and 2,3-substituted isomers), hexamethylene glycol (1,2-, 1,3-, 1,4-1,5-, 1,6-, 2,3-, 2,4-, 2,5-, 3,4-substituted isomers);

or their mixtures.

3. The polymer of claim 1 wherein Y and Z of L1 are independently selected from

4. The polymer of claim 1 wherein Y and Z of L1 are independently selected from

5. The polymer of claim 1 with the following formula

6. A polymer consisting of two blocks wherein

a) the first block has the formula