Method and device for analysing a liquid
First Claim
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1. A device for determining the coagulation state of a sample comprising:
- a sample chamber defining a volume for receiving a sample to be analysed, the sample chamber having a sample chamber major axis;
at least one particle disposed within the chamber volume wherein the at least one particle comprises at least one material which experiences a force when placed in a magnetic field;
a first electromagnet and a second electromagnet for applying a magnetic field to at least part of the chamber volume, the first electromagnet being spaced apart from the second electromagnet by the sample chamber, the first electromagnet having a first electromagnet major axis, the second electromagnet having a second electromagnet major axis, and the first electromagnet major axis and the second electromagnet major axis being parallel to the sample chamber major axis;
at least one sensor operative to detect a response, along the sample chamber major axis, of the at least one particle to the magnetic field; and
a processor configured to determine the coagulation state of the sample based on the response, along the sample chamber major axis, of the at least one particle to the magnetic field.
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Abstract
Novel methods and devices comprising magnetic particles for detecting or monitoring the coagulation state of a sample are provided.
33 Citations
29 Claims
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1. A device for determining the coagulation state of a sample comprising:
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a sample chamber defining a volume for receiving a sample to be analysed, the sample chamber having a sample chamber major axis; at least one particle disposed within the chamber volume wherein the at least one particle comprises at least one material which experiences a force when placed in a magnetic field; a first electromagnet and a second electromagnet for applying a magnetic field to at least part of the chamber volume, the first electromagnet being spaced apart from the second electromagnet by the sample chamber, the first electromagnet having a first electromagnet major axis, the second electromagnet having a second electromagnet major axis, and the first electromagnet major axis and the second electromagnet major axis being parallel to the sample chamber major axis; at least one sensor operative to detect a response, along the sample chamber major axis, of the at least one particle to the magnetic field; and a processor configured to determine the coagulation state of the sample based on the response, along the sample chamber major axis, of the at least one particle to the magnetic field. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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29. A method of determining the coagulation state of a sample comprising:
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providing a sample in a sample chamber, the sample chamber having a major axis, and the sample containing at least one particle comprising a material which experiences a force when placed in a magnetic field; applying a magnetic field to said sample using a first electromagnet and a second electromagnet, the first electromagnet being spaced apart from the second electromagnet by the sample chamber, the first electromagnet having a first electromagnet major axis, the second electromagnet having a second electromagnet major axis, and the first electromagnet major axis and the second electromagnet major axis being parallel to the sample chamber major axis; and using a sensor to detect a response, along the sample chamber major axis, of the at least one particle to the magnetic field to determine the coagulation state of the sample.
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Specification