Droplet-based surface modification and washing
First Claim
1. A method of providing a droplet in contact with a surface with a reduced concentration of a substance, the method comprising:
- (a) providing an automated droplet microactuator comprising at least one surface in contact with a droplet comprising a starting concentration and starting quantity of the substance and having a starting volume;
(b) conducting by automation one or more droplet operations to merge a wash droplet with the droplet provided in step (a) to yield a combined droplet; and
(c) conducting by automation one or more droplet operations to divide the combined droplet to yield a set of droplets comprising;
(i) a droplet in contact with the at least one surface having a decreased concentration of the substance relative to the starting concentration; and
(ii) a droplet which is separated from the at least one surface.
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Abstract
The present invention relates to droplet-based surface modification and washing. According to one embodiment, a method of providing a droplet in contact with a surface with a reduced concentration of a substance is provided, wherein the method includes: (a) providing a droplet microactuator comprising a surface in contact with a droplet comprising a starting concentration and starting quantity of the substance and having a starting volume; (b) conducting one or more droplet operations to merge a wash droplet with the droplet provided in step (a) to yield a combined droplet; and (c) conducting one or more droplet operations to divide the combined droplet to yield a set of droplets comprising: (i) a droplet in contact with the surface having a decreased concentration of the substance relative to the starting concentration; and (ii) a droplet which is separated from the surface.
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Citations
60 Claims
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1. A method of providing a droplet in contact with a surface with a reduced concentration of a substance, the method comprising:
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(a) providing an automated droplet microactuator comprising at least one surface in contact with a droplet comprising a starting concentration and starting quantity of the substance and having a starting volume; (b) conducting by automation one or more droplet operations to merge a wash droplet with the droplet provided in step (a) to yield a combined droplet; and (c) conducting by automation one or more droplet operations to divide the combined droplet to yield a set of droplets comprising; (i) a droplet in contact with the at least one surface having a decreased concentration of the substance relative to the starting concentration; and (ii) a droplet which is separated from the at least one surface. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60)
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Specification