System and method for managing detrimental cardiac remodeling

• US 7,440,800 B2
• Filed: 05/31/2005
• Issued: 10/21/2008
• Est. Priority Date: 08/19/1996
• Status: Expired due to Fees

• Current Assignee: MR3 Medical, LLC
• Original Assignee: MR3 Medical, LLC
• Inventors: Mower, Morton M.
• Primary Examiner(s): Getzow; Scott M
• Application Number:
  US11/141,403
• Publication Number:
  US 20050277993A1
• Time in Patent Office: 1,239 Days
• Field of Search: 607 4- 28
• US Class Current: 607/9
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation

Abstract

A system and method for managing and inhibiting cardiac remodeling in MI patients. Bi-ventricular stimulation is constantly provided with and without sensing to encourage normal pumping of the heart on a consistent basis. Pulses are administered using an anodal pulse followed by a cathodal pulse to stimulate cardiac muscle contraction. Stem cells are administered to MI areas to encourage regeneration of cardiac tissue in the damaged area. Stimulation may be provided to both healthy and compromised cardiac tissue.

Claims

1. An apparatus for minimizing cardiac remodeling of a non-arrhythmic patient comprising:

a heart stimulation device adapted to stimulate cardiac tissue, wherein the cardiac tissue comprises healthy and compromised areas;

a left ventricular electrode group, wherein the left ventricular electrode group comprises LV electrodes attached to the left ventricle at increasing distances from the AV node; and

a right ventricular electrode group, wherein the right ventricular electrode group comprises RV electrodes attached to the left ventricle at increasing distances from the AV node, and

wherein, the heart stimulation device is further adapted to;

attach to the LV and RV electrodes;

generate a timing signal coincident with a refractory period; and

in response to the timing signal, send pulses to the LV and RV electrodes sequenced such that an initial pulse arrives at an LV electrode and at an RV electrode nearest the AV junction and subsequent pulses arrive at an LV and at an RV electrode progressively further from the AV junction.

2. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient of claim 1, wherein the pulse is excitatory.

3. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient of claim 1, wherein the pulse is non-excitatory.

4. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient according to claim 1, wherein a compromised area of cardiac tissue has stem cells deposited thereon.

5. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient according to claim 4, wherein the LV and RV electrodes are located so as to electrically stimulate the compromised area of cardiac tissue on which stem cells have been deposited.

6. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient according to claim 4, wherein the LV and RV electrodes are located so as to preclude electrical stimulation of the compromised area of cardiac tissue on which stem cells have been deposited.

7. An apparatus for minimizing cardiac remodeling of a non-arrhythmic patient comprising:

a heart stimulation device adapted to stimulate cardiac tissue, wherein the cardiac tissue comprises healthy and compromised areas;

a left ventricular electrode group, wherein the left ventricular electrode group comprises LV electrodes attached to the left ventricle at increasing distances from the AV node;

a right ventricular electrode group, wherein the right ventricular electrode group comprises RV electrodes attached to the left ventricle at increasing distances from the AV node; and

a sensor, and

wherein, the sensor is adapted to sense excitation of a heart chamber, and

wherein, the heart stimulation device is further adapted to;

attach to the LV and RV electrodes;

attach to the sensor; and

in response to a signal from the sensor, send pulses to the LV and RV electrodes sequenced such that an initial pulse arrives at an LV electrode and at an RV electrode nearest the AV junction and subsequent pulses arrive at an LV and at an RV electrode progressively further from the AV junction.

8. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient of claim 7, wherein the pulse is excitatory.

9. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient of claim 7, wherein the pulse is non-excitatory.

10. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient according to claim 7, wherein a compromised area of cardiac tissue has stem cells deposited thereon.

11. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient according to claim 10, wherein the LV and RV electrodes are located so as to electrically stimulate the compromised area of cardiac tissue on which stem cells have been deposited.

12. The apparatus for minimizing cardiac remodeling of a non-arrhythmic patient according to claim 10, wherein the LV and RV electrodes are located so as to preclude electrical stimulation of the compromised area of cardiac tissue on which stem cells have been deposited.

13. A method for minimizing cardiac remodeling of a non-arrhythmic patient comprising:

administering stem cells to a myocardial infarct (MI) area of a patient;

continuously administering biphasic bi-ventricular stimulation to cardiac tissue outside of the MI area, wherein the biphasic stimulation comprises;

a first stimulation phase having a first phase polarity, a first phase amplitude, a first phase shape, and a first phase duration, so as to precondition the myocardium to accept subsequent stimulation, and a second stimulation phase having a second phase polarity, a second phase amplitude that is larger in absolute value than the first phase amplitude, a second phase shape, and a second phase duration.

14. The method for minimizing cardiac remodeling of a non-arrhythmic patient of claim 13 wherein the first phase polarity is positive, and the second phase polarity is negative.

15. The method for minimizing cardiac remodeling of a non-arrhythmic patient of claim 13 wherein the first phase amplitude is at a maximum subthreshold amplitude.

16. The method for minimizing cardiac remodeling of a non-arrhythmic patient of claim 13 wherein the biphasic stimulation is administered so as to electrically stimulate the MI area to which stem cells have been administered.

17. The method for minimizing cardiac remodeling of a non-arrhythmic patient according to claim 13, wherein the biphasic stimulation is administered so as to preclude electrical stimulation of the MI area to which stem cells have been administered.