Bioactive agent release coating
First Claim
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1. A method of adjusting the rate of release of one or more bioactive agents from a medical device comprising;
- providing a medical device having one or more surfaces;
applying a mixture to the one or more surfaces, the mixture comprising hydrophobic polymers in combination with one or more bioactive agents;
wherein the hydrophobic polymers comprise at least one poly(alkyl)(meth)acrylate and at least one poly(ethylene-co-vinyl acetate); and
adjusting the relative concentrations of hydrophobic polymers in the mixture to control the rate of release of the bioactive agent.
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Abstract
A coating composition for use in coating implantable medical devices to improve their ability to release bioactive agents in vivo. The coating composition is particularly adapted for use with devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a mixture of a first polymer component such as poly(butyl methacrylate) and a second polymer component such as poly(ethylene-co-vinyl acetate).
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Citations
19 Claims
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1. A method of adjusting the rate of release of one or more bioactive agents from a medical device comprising;
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providing a medical device having one or more surfaces; applying a mixture to the one or more surfaces, the mixture comprising hydrophobic polymers in combination with one or more bioactive agents;
wherein the hydrophobic polymers comprise at least one poly(alkyl)(meth)acrylate and at least one poly(ethylene-co-vinyl acetate); andadjusting the relative concentrations of hydrophobic polymers in the mixture to control the rate of release of the bioactive agent. - View Dependent Claims (2, 3)
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4. A combination comprising:
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a medical device having one or more surfaces; a mixture carried on the one or more surfaces, the mixture comprising complementary hydrophobic polymers in combination with one or more bioactive agents, wherein individual hydrophobic polymer concentrations in the mixture are between about 0.05 and about 70 weight percent;
wherein the complementary hydrophobic polymers comprise at least one poly(alkyl)(meth)acrylate and at least one poly(ethylene-co-vinyl acetate). - View Dependent Claims (5, 6)
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7. A combination comprising:
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a stent having one or more surfaces; a mixture carried on the one or more surfaces, the mixture comprising a plurality of polymers, including a first polymer component comprising a poly(alkyl)(meth)acrylate and a second polymer component comprising a poly(ethylene-co-vinyl acetate) in combination with one or more bioactive agents, wherein the first polymer and the second polymer concentrations in the mixture are each between about 0.05 and about 70 weight percent. - View Dependent Claims (8, 9, 10, 11, 12, 13)
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14. A combination comprising:
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a medical device having one or more surfaces; a mixture carried on the one or more surfaces, the mixture consisting essentially of a first hydrophobic polymer and a second hydrophobic polymer and a bioactive agent, wherein the first hydrophobic polymer and the second hydrophobic polymer each have a concentration in the mixture between about 0.05 and about 70 weight percent;
wherein the first hydrophobic polymer is a poly(alkyl)(meth)acrylate and the second hydrophobic polymer is a poly(ethylene-co-vinyl acetate). - View Dependent Claims (15, 16)
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17. A method of adjusting the rate of release of one or more bioactive agents from a medical device comprising;
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providing a medical device having one or more surfaces; applying a mixture to the one or more surfaces, the mixture comprising a first hydrophobic polymer and a second hydrophobic polymer in combination with one or more bioactive agents; and adjusting the relative concentrations of the first and second hydrophobic polymers in the mixture to either increase or decrease the release rate of the bioactive agent as desired;
wherein the hydrophobic polymers comprise at least one poly(alkyl)(meth)acrylate and at least one poly(ethylene-co-vinyl acetate). - View Dependent Claims (18, 19)
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Specification