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Medical device and method for diagnostic sensing

  • US 7,445,766 B2
  • Filed: 04/10/2006
  • Issued: 11/04/2008
  • Est. Priority Date: 03/02/2000
  • Status: Expired due to Fees
First Claim
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1. A method of detecting an analyte in vivo comprising:

  • implanting at a site in a patient a device which comprises;

    one or more discrete reservoirs each containing at least one reacting component,at least one non-degradable barrier layer covering an opening in each of the one or more discrete reservoirs, the non-degradable barrier layer being selectively permeable to an analyte to be detected, wherein the reacting component remains inside the reservoirs, anda degradable barrier layer, which is impermeable to the analyte to be detected and which covers the at least one non-degradable barrier layer over the reservoir opening;

    disintegrating or permeabilizing the degradable barrier layer over at least one of the reservoirs to permit the analyte at the site to enter the reservoir and react with the at least one reacting component; and

    using a sensor positioned externally from the reservoir to detect the reaction between the reacting component and the analyte.

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