Medical device having a hydration inhibitor
First Claim
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1. A medical device comprising:
- an interventional component to be deployed in a patient;
a beneficial agent to be delivered from the interventional component, the beneficial agent loaded on at least a portion of the interventional component and having a first Log P value; and
an effective amount of a hydration inhibitor associated with the beneficial agent to control delivery of the beneficial agent from the interventional component, the hydration inhibitor having a second Log P value, the second Log P value being greater than the first Log P value, wherein the effective amount of the hydration inhibitor is an amount sufficient to shift the liquid-solid contact angle of the beneficial agent in association with the hydration inhibitor to at least 50 degrees.
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Abstract
A medical device having a hydration inhibitor for controlled delivery of a beneficial agent and methods of manufacturing of the same. The medical device includes an interventional component loaded with a beneficial agent having a first Log P value, the beneficial agent being associated with a hydration inhibitor to control the elution rate of at least part of the beneficial agent, the hydration inhibitor having a second Log P value which is greater than the first Log P value.
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Citations
59 Claims
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1. A medical device comprising:
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an interventional component to be deployed in a patient; a beneficial agent to be delivered from the interventional component, the beneficial agent loaded on at least a portion of the interventional component and having a first Log P value; and an effective amount of a hydration inhibitor associated with the beneficial agent to control delivery of the beneficial agent from the interventional component, the hydration inhibitor having a second Log P value, the second Log P value being greater than the first Log P value, wherein the effective amount of the hydration inhibitor is an amount sufficient to shift the liquid-solid contact angle of the beneficial agent in association with the hydration inhibitor to at least 50 degrees. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. A method of manufacturing a medical device, the method comprising the steps of:
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providing an interventional component to be deployed in a patient; loading a beneficial agent on the interventional component for delivery therefrom, the beneficial agent having a first Log P value; and associating an effective amount of a hydration inhibitor with the beneficial agent to control delivery of the beneficial agent from the interventional component, the hydration inhibitor having a second Log P value, the second Log P value being greater than the first Log P value, wherein the effective amount of the hydration inhibitor is an amount sufficient to shift the liquid-solid contact angle of the beneficial agent in association with the hydration inhibitor to at least 50 degrees. - View Dependent Claims (27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51)
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52. A medical device comprising:
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an interventional component to be deployed in a patient; a beneficial agent to be delivered from the interventional component, the beneficial agent loaded on at least a portion of the interventional component and having a first Log P value; and an effective amount of a hydration inhibitor associated with the beneficial agent to enhance the stability of the moisture sensitive beneficial agent to be delivered from the interventional component, the hydration inhibitor having a second Log P value, the second Log P value being greater than the first Log P value, wherein the effective amount of the hydration inhibitor is an amount sufficient to shift the liquid-solid contact angle of the beneficial agent in association with the hydration inhibitor to at least 50 degrees. - View Dependent Claims (53, 54, 55, 56, 57, 58, 59)
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Specification