Nucleic acids encoding chimeric T cell receptors
DC CAFCFirst Claim
1. A nucleic acid polymer encoding a chimeric T cell receptor, said chimeric T cell receptor comprising(a) a zeta chain portion comprising the intracellular domain of human CD3 ζ
- chain,(b) a costimulatory signaling region, and(c) a binding element that specifically interacts with a selected target, wherein the costimulatory signaling region comprises the amino acid sequence encoded by SEQ ID NO;
6.
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Accused Products
Abstract
Chimeric T cell receptors (TCR) are provided that combine, in a single chimeric species, the intracellular domain of CD3 ζ-chain, a signaling region from a costimulatory protein such as CD28, and a binding element that specifically interacts with a selected target. When expressed, for example in T-lymphocytes from the individual to be treated for a condition associated with the selected target, a T cell immune response is stimulated in the individual to the target cells. The chimeric TCR'"'"'s are able to provide both the activation and the co-stimulation signals from a single molecule to more effectively direct T-lymphocyte cytotoxicity against the selected target and T-lymphocyte proliferation.
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Citations
13 Claims
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1. A nucleic acid polymer encoding a chimeric T cell receptor, said chimeric T cell receptor comprising
(a) a zeta chain portion comprising the intracellular domain of human CD3 ζ - chain,
(b) a costimulatory signaling region, and (c) a binding element that specifically interacts with a selected target, wherein the costimulatory signaling region comprises the amino acid sequence encoded by SEQ ID NO;
6. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
- chain,
Specification