Monitoring subcortical responsiveness of a patient
First Claim
1. A method for monitoring subcortical responsiveness of a patient, the method comprising the steps of:
- acquiring at least one first physiological measurement signal from a patient using at least one sensor, the physiological measurement signal being one of the signals in a group including an RRI signal, a plethysmographic signal, an EMG signal, a blood pressure signal, and a signal representing skin conductivity;
deriving at least one second measurement signal from the at least one first measurement signal, said at least one second measurement signal being indicative of pain-related activity in the patient;
supplying a predetermined stimulus signal to the patient to cause pain to the patient, wherein the predetermined stimulus signal is supplied in synchronization with a spontaneous rhythm of the patient that is regulated by the autonomous nervous system of the patient;
monitoring a response caused by the stimulus signal in the at least one second measurement signal, wherein the monitoring step is synchronized with the supplying step;
determining, based on the monitoring step, an indicator of subcortical responsiveness, said indicator being indicative of the patient'"'"'s level of antinociception; and
outputting the indicator of subcortical responsiveness to a device.
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Accused Products
Abstract
To monitor subcortical responsiveness of a patient at least one first measurement signal is acquired from a patient and at least one second measurement signal is derived from the at least one first measurement signal. The second measurement signal is indicative of pain-related activity in the patient. A predetermined stimulus signal is then supplied to the patient and a response caused by the stimulus signal in the at least one second measurement signal is monitored in synchronization with the supplying of the stimulus signal. Based on the monitoring step, an indicator of subcortical responsiveness is determined, the indicator being indicative of the patient'"'"'s level of antinociception.
95 Citations
24 Claims
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1. A method for monitoring subcortical responsiveness of a patient, the method comprising the steps of:
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acquiring at least one first physiological measurement signal from a patient using at least one sensor, the physiological measurement signal being one of the signals in a group including an RRI signal, a plethysmographic signal, an EMG signal, a blood pressure signal, and a signal representing skin conductivity; deriving at least one second measurement signal from the at least one first measurement signal, said at least one second measurement signal being indicative of pain-related activity in the patient; supplying a predetermined stimulus signal to the patient to cause pain to the patient, wherein the predetermined stimulus signal is supplied in synchronization with a spontaneous rhythm of the patient that is regulated by the autonomous nervous system of the patient; monitoring a response caused by the stimulus signal in the at least one second measurement signal, wherein the monitoring step is synchronized with the supplying step; determining, based on the monitoring step, an indicator of subcortical responsiveness, said indicator being indicative of the patient'"'"'s level of antinociception; and outputting the indicator of subcortical responsiveness to a device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. The method for monitoring subcortical responsiveness of a patient, the method comprising the steps of:
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measuring at least two physiological signals from the patient using at least one sensor, the at least two physiological signals belonging to a group including an RRI signal, a plethysmographic signal, an EMG signal, a blood pressure signal, and a signal representing skin conductivity; deriving at least two second measurement signals from the at least two physiological signals, the at least two second measurement signals being indicative of rain-related activity in the patient; supplying a predetermined stimulus signal to the patient;
monitoring a response caused by the stimulus signal in the at least two second measurement signals, wherein the monitoring step is synchronized with the supply step;determining, based upon a combination of the responses in the at least two second measurement signals monitored in the monitoring step, an indicator of subcortical responsiveness, the indicator being indicative of the patient'"'"'s level of antinociception; and outputting the indicator of subcortical responsiveness to a device. - View Dependent Claims (17, 18, 19)
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20. An apparatus for monitoring the subcortical responsiveness of a patient, the apparatus comprising:
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first means for acquiring a plurality of first measurement signals from a patient, the first measurement signals being signals from a group including an RRI signal, a plethysmographic signal, an EMG signal, a blood pressure signal and a signal representing skin conductivity; second means for deriving a plurality of second measurement signals from the first measurement signals, the second measurement signals being indicative of pain-related activity in the patient; stimulator means for supplying a predetermined stimulus signal to the patient; third means for monitoring a response caused by the stimulus signal in the second measurement signals, the third means being synchronized with the stimulator means; and fourth means, responsive to the third means, for determining an indicator of subcortical responsiveness based upon the response caused in the plurality of second measurement signals, said indicator being indicative of the patient'"'"'s level of antinociception. - View Dependent Claims (21, 22, 23, 24)
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Specification